Clostridium difficile infection in pregnant and postpartum women in 2 hospitals and a review of literature
| Autor: | Shamma Mumtaz, Nilangi Virgincar, Alyson Smith, Michaela Hooper, Neil Macdonald, Charlotte Anderson, Victoria Gentry, Amanda Walker, Manjula Meda, Simon Wells, David Garner |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Pediatrics Epidemiology medicine.drug_class Antibiotics Disease cluster 03 medical and health sciences 0302 clinical medicine Pregnancy Recurrence Risk Factors medicine Hospital discharge Cluster Analysis Humans Infection control 030212 general & internal medicine Pregnancy Complications Infectious Feces Cross Infection 0303 health sciences 030306 microbiology business.industry Health Policy Postpartum Period Public Health Environmental and Occupational Health Environmental Exposure Clostridium difficile medicine.disease Hospitals Anti-Bacterial Agents Infectious Diseases England Clostridium Infections Female business |
| Zdroj: | American Journal of Infection Control. 47:e7-e14 |
| ISSN: | 0196-6553 |
| DOI: | 10.1016/j.ajic.2018.06.001 |
| Popis: | Background Healthcare-associated Clostridium difficile infection (CDI) in pregnant/postpartum women is underreported, especially outside of North America. We report a cluster of cases in 2 neighboring secondary care hospitals in South-East England. The objective of this study was to identify the epidemiology and risk factors for infection. Methods An investigation into a cluster of cases of confirmed CDI in pregnant/postpartum women was performed over a 12-month period, from June 2016 to June 2017. Results Eleven cases, in 10 patients, were identified, including 1 patient who had a relapse. Eight of 10 patients developed symptoms after hospital discharge. All patients had received broad-spectrum antibiotics prior to CDI onset. Environmental vectors, such as labor room mattresses, that were found difficult to effectively decontaminate after heavy contamination with blood, feces, and other body fluids may have been possible reservoirs. An infection control care bundle was successful in preventing further cases. Conclusions Antibiotic use and exposure to the organism in a contaminated labor room environment are likely risk factors for healthcare-associated CDI in postpartum women. Active surveillance is necessary to prevent these infections, as these cases often present after hospital discharge. |
| Databáze: | OpenAIRE |
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