Effects ofin Uteroand Lactational Exposure of the Laboratory Rat to 2,4,2′,4′- and 3,4,3′,4′-Tetrachlorobiphenyl on Dopamine Function
| Autor: | Richard F. Seegal, Richard J. Okoniewski, Karl O. Brosch |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Offspring Dopamine medicine.medical_treatment Caudate nucleus Substantia nigra Biology Toxicology chemistry.chemical_compound Fetus Pregnancy Internal medicine medicine Animals Lactation Brain Chemistry Pharmacology Dose-Response Relationship Drug Body Weight Homovanillic acid Homovanillic Acid Polychlorinated Biphenyls Rats Laboratory rat Steroid hormone Endocrinology chemistry 3 4-Dihydroxyphenylacetic Acid Female Breast feeding medicine.drug |
| Zdroj: | Toxicology and Applied Pharmacology. 146:95-103 |
| ISSN: | 0041-008X |
| Popis: | Offspring of Sprague–Dawley derived dams were exposed to either 2,4,2′,4′-tetrachlorobiphenyl (TCB) (1, 10, or 20 mg/(kg·day)) or 3,4,3′,4′-TCB (0.1 or 1 mg/(kg·day)) from gestational Day 6 through weaning by providing the dams with cookies adulterated with the appropriate amount and type of PCB. Male and female offspring were sacrificed on postnatal Days 35, 60, and 90, and brain concentrations of dopamine and its metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid, were determined in the frontal cortex, caudate nucleus and substantia nigra by high-performance liquid chromatography with electrochemical detection.In uteroand lactational exposure to 3,4,3′,4′-TCB resulted in significant elevations in concentrations of dopamine in the frontal cortex, and of dopamine and its metabolites in the substantia nigra that persisted into adulthood. In contrast,in uteroand lactational exposure to 2,4,2′,4′-TCB resulted in significant decreases in concentrations of dopamine in the frontal cortex and caudate nucleus that also persisted into adulthood. We suggest that the reductions in brain dopamine concentrations are a consequence ofortho-substituted PCB congener-induced inhibition of the synthesis of dopamine during critical periods of development acting, perhaps, in concert with PCB-induced changes in cholinergic receptor function. On the other hand, the persistent elevations in brain dopamine and metabolite concentrations following perinatal exposure to 3,4,3′,4′-TCB may be mediated by alterations in steroid hormone function during key developmental periods. |
| Databáze: | OpenAIRE |
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