Increased Expression of Proatherogenic Proteins in Immune Cell Subtypes in Tobacco Cigarette Smokers But Not in Electronic Cigarette Vapers

Autor: Yuyan Zhang, Theodoros Kelesidis, Elizabeth Tran, Grace Sosa, Holly R. Middlekauff
Rok vydání: 2021
Předmět:
Male
T-Lymphocytes
030204 cardiovascular system & hematology
Cardiorespiratory Medicine and Haematology
Electronic Nicotine Delivery Systems
Cardiovascular
Monocytes
law.invention
Nicotine
0302 clinical medicine
law
Killer Cells
2.1 Biological and endogenous factors
030212 general & internal medicine
Receptor
Cancer
Caspase 1
Substance Abuse
Inflammasome
Middle Aged
Flow Cytometry
Killer Cells
Natural
medicine.anatomical_structure
Natural
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.drug
Adult
Drug Abuse (NIDA Only)
Inflammation
Cigarette Smoking
03 medical and health sciences
Young Adult
Immune system
Clinical Research
Tobacco
medicine
Humans
Tobacco Smoke and Health
business.industry
Monocyte
Prevention
Toll-Like Receptor 4
Cardiovascular System & Hematology
Interleukin-6 Receptor alpha Subunit
Immunology
TLR4
business
Electronic cigarette
Zdroj: The Canadian journal of cardiology, vol 37, iss 8
ISSN: 1916-7075
Popis: It is unclear how oxidative stress triggered by smoking and vaping may alter specific immune cell subsets. In this study, we showed that tobacco cigarette smoking, but not electronic-cigarette vaping, is associated with increased expression of major proteins in the toll-like receptor 4 (TLR4) inflammasome-interleukin (IL)-6 signalling axis in monocyte subtypes and T cells. TLR4 senses oxidative stress in immune cells caspase-1 is a key protein of inflammasome activation, and IL-6R-α is the receptor for IL-6 that drives proatherogenic IL-6 signalling. These findings implicate the non-nicotine, pro-oxidant toxicants in tobacco cigarette smoke as instigators of increased expression of key proteins in the TLR4-inflammasome-IL-6 axis that contribute to atherogenesis.
Databáze: OpenAIRE
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