Electrospun Polyvinylpyrrolidone-Gelatin and Cellulose Acetate Bi-Layer Scaffold Loaded with Gentamicin as Possible Wound Dressing
| Autor: | Verónica Almaguer-Cantú, Hector Daniel Lopez-Calderon, C. Calderón-Ramón, J. E. Escalante-Martínez, J.R. Laguna-Camacho, Luis J. Galán-Wong, Hamlet Avilés-Arnaut, Katiushka Arévalo-Niño |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
food.ingredient Polymers and Plastics wound dressing Gelatin Article Contact angle lcsh:QD241-441 chemistry.chemical_compound food lcsh:Organic chemistry nanofibers medicine Fourier transform infrared spectroscopy electrospinning Polyvinylpyrrolidone biomaterial Biomaterial General Chemistry Cellulose acetate Electrospinning antibacterial Chemical engineering chemistry Nanofiber medicine.drug |
| Zdroj: | Polymers, Vol 12, Iss 2311, p 2311 (2020) Polymers Volume 12 Issue 10 |
| ISSN: | 2073-4360 |
| Popis: | Acceleration of wound healing can be achieved with the use of wound dressings. Through the electrospinning technique, a polymeric scaffold composed of two layers was processed: a gelatin and polyvinylpyrrolidone layer with gentamicin, and a second layer of cellulose acetate. The conditions for the electrospinning process were standardized for voltage parameters, feed flow and the distance from the injector to the collector. Once the values of the main variables for the electrospinning were optimized, a three-hour processing time was established to allow the separation of the material from the collector. The obtained material was characterized by observations on scanning electron microscopy, Fourier transform infrared spectroscopy and thermal analysis contact angle measurement was performed to evaluate wettability properties, and antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus were evaluated using the Kirby&ndash Bauer test. The obtained fibers that form the bi-layer scaffold present diameters from 100 to 300 nm. The scaffold presents chemical composition, thermal stability, wettability characteristics and antibacterial activity that fulfill the proposal from this study, based on obtaining a scaffold that could be used as a drug delivery vehicle and a wound dressing material. |
| Databáze: | OpenAIRE |
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