Outcome of paraaortic node-positive pancreatic head and bile duct adenocarcinoma
| Autor: | Seigo Kitano, Toshifumi Matsumoto, Takanori Yoshida, Kohei Shibata, Atsushi Sasaki, Masanori Aramaki |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Adenocarcinoma Cholangiocarcinoma Pancreatectomy Paraaortic lymph nodes Humans Medicine Survival rate Lymph node Bile Duct Adenocarcinoma Retrospective Studies Pancreatic duct business.industry General Medicine Middle Aged Surgery Pancreatic Neoplasms Survival Rate Periampullary Adenocarcinoma medicine.anatomical_structure Bile Duct Neoplasms Biliary tract Lymphatic Metastasis Lymph Node Excision Female Lymph Nodes Radiology business |
| Zdroj: | The American Journal of Surgery. 187:736-740 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/j.amjsurg.2003.07.031 |
| Popis: | Background This retrospective study aimed to identify the clinicopathologic features and surgical results of paraaortic node-positive periampullary adenocarcinoma. Methods Between 1995 and 1999, 101 patients underwent pancreatectomy with regional and paraaortic lymphadenectomy. Fifteen (15%) patients had histologically proven paraaortic lymph node disease. Results The 15 patients included 9 (26%) of 34 patients with pancreatic head carcinoma and 6 (17%) of 36 patients with bile duct adenocarcinoma. All 15 patients had locally advanced tumor invading adjacent structures. The 1-, 2-, and 3-year survival rates were 33%, 27%, and 0%, with median survival of 12 months (range 3 to 33). In patients with pancreatic head carcinoma or bile duct adenocarcinoma, survival curve for those without paraaortic lymph node metastasis was significantly better than that for those with involved paraaortic lymph nodes (P = 0.0033 or P = 0.0149). Conclusions When the paraaortic lymph nodes obtained from sampling biopsy are histologically positive, radical pancreatectomy with extended lymphatic and soft tissue clearance should be abandoned owing to poor outcome. |
| Databáze: | OpenAIRE |
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