[Usefulness of high-sensitivity CRP increases during circadian rhythm for prediction of long-term cardiovascular events in patients with stable coronary artery disease]

Autor: Esra Dönmez, Mevlüt Koç, Onur Kadir Uysal, Gulcan Abali, Osman Karaarslan, Mustafa Kemal Batur, Durmuş Yıldıray Şahin
Rok vydání: 2011
Předmět:
Zdroj: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. 39(7)
ISSN: 1016-5169
Popis: OBJECTIVES We investigated the value of circadian variations in high-sensitivity C-reactive protein (hs-CRP) levels in prediction of long-term cardiovascular events (CVE) in patients with stable coronary artery disease (CAD). STUDY DESIGN The study included 94 patients (70 men, 24 women; mean age 58 ± 9 years) with stable CAD. High-sensitivity CRP levels were measured at six-hour intervals, namely, morning (06:00), midday (12:00), evening (18:00), and midnight (24:00). Absolute change in hs-CRP (absolute ΔCRP) was calculated by subtracting the midday hs-CRP level from that of the morning. Relative change in hs-CRP (relative ΔCRP) was calculated by dividing absolute ΔCRP by the midday hs-CRP level. The patients were followed-up for a mean of 40.2 ± 8.0 months for monitoring of CVE. RESULTS During the follow-up period, CVE occurred in 24 patients (25.5%). Patients who developed CVE exhibited significantly higher serum creatinine, B-type natriuretic peptide, morning, evening, and midnight hs-CRP levels, absolute and relative ΔCRP, and left atrial end-diastolic diameter compared to patients without CVE (p
Databáze: OpenAIRE
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