Carbon-14 labeling of K777•HCl, a therapeutic agent for Chagas disease

Autor:	Wallace W. Bradford, Sung-Whi Rhee, Mary J. Tanga, Jeremiah P. Malerich
Rok vydání:	2013
Předmět:	Drug Chagas disease Vinyl Compounds Stereochemistry Phenylalanine media_common.quotation_subject Biochemistry Piperazines Absorption Analytical Chemistry Tosyl Compounds Excretion Drug Discovery medicine Distribution (pharmacology) Chagas Disease Radiology Nuclear Medicine and imaging Carbon Radioisotopes Trypanosoma cruzi Spectroscopy media_common biology Chemistry Organic Chemistry Dipeptides Metabolism biology.organism_classification medicine.disease Isotope Labeling Carbon-14 Specific activity Nuclear chemistry
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 56:461-463
ISSN:	0362-4803
DOI:	10.1002/jlcr.3107
Popis:	The antitrypanosomal agent K777•HCl was labeled with carbon-14 to support absorption, distribution, metabolism, and excretion studies of this potential new drug for the treatment of Chagas disease. The radiolabeled compound was prepared in eight steps from [(14) C(U)]-(l)-phenylalanine with a specific activity of 54.4 mCi/mmol and an overall radiochemical yield of 4.1%.
Databáze:	OpenAIRE
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