Epigallocatechin-3-gallate prevents inflammation and diabetes -Induced glucose tolerance through inhibition of NLRP3 inflammasome activation
| Autor: | Xiang Hu, Cheng Zhang, Lianlian Li, Yutao Diao, Yanqi Zhang, Haipeng Yin, Qirui Xu, Xin Li, Jie Yu, Xiaoyu Zhang, Jun Peng, Hongyan Liu |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Inflammasomes Immunology Anti-Inflammatory Agents Inflammation Type 2 diabetes Pharmacology Diet High-Fat complex mixtures Catechin Mice 03 medical and health sciences 0302 clinical medicine Bone Marrow In vivo Diabetes mellitus NLR Family Pyrin Domain-Containing 3 Protein Pyroptosis medicine Animals Humans Immunology and Allergy heterocyclic compounds Secretion Cells Cultured integumentary system Chemistry Macrophages food and beverages Inflammasome Glucose Tolerance Test medicine.disease In vitro Mice Inbred C57BL Disease Models Animal 030104 developmental biology Diabetes Mellitus Type 2 030220 oncology & carcinogenesis sense organs medicine.symptom medicine.drug |
| Zdroj: | International Immunopharmacology. 93:107412 |
| ISSN: | 1567-5769 |
| DOI: | 10.1016/j.intimp.2021.107412 |
| Popis: | Epigallocatechin-3-gallate (EGCG), the primary polyphenol component of green tea, has been shown to inhibit both oxidation and inflammation. However, the exact mechanism through which EGCG exhibits anti-inflammatory effects remains unclear. In this study, we assessed the potential pathways by which EGCG regulates NLRP3 inflammasome activity in vitro. We found that EGCG inhibits caspase-1 activation and IL-1β secretion by suppressing NLRP3 inflammasome activation in mouse bone marrow-derived macrophages (BMDMs). EGCG was also observed to block NLRP3-mediated ASC speckle formation and to alleviate pyroptosis in BMDMs. In addition, EGCG treatment could improve high-fat diet (HFD)-induced glucose tolerance and prevent NLRP3 inflammasome-dependent inflammation in a mouse model of HFD-induced type 2 diabetes (T2D). Taken together, our results show that EGCG is a general inhibitor of NLRP3 inflammasome activation and administration of EGCG in T2D mice could improve glucose tolerance in vivo. |
| Databáze: | OpenAIRE |
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