Evaluation of superoxide dismutase from Helicobacter pylori as a protective vaccine antigen
| Autor: | Caroline D Skene, Philip Sutton, Stirling John Edwards, Alison L. Every, Margaret Bridget Holland Moloney, Garrett Z. Ng, Andrew Stent |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Helicobacter Infections
Microbiology Superoxide dismutase Mice 03 medical and health sciences Antigen Immunity Escherichia coli Gastric mucosa medicine Animals 030304 developmental biology chemistry.chemical_classification Antigens Bacterial 0303 health sciences Reactive oxygen species Helicobacter pylori General Veterinary General Immunology and Microbiology biology Superoxide Dismutase 030306 microbiology Public Health Environmental and Occupational Health biology.organism_classification Antibodies Bacterial Recombinant Proteins Immunity Humoral 3. Good health Mice Inbred C57BL Bacterial vaccine Infectious Diseases medicine.anatomical_structure chemistry Bacterial Vaccines Immunology biology.protein Molecular Medicine Female Antibody |
| Zdroj: | Vaccine. 29:1514-1518 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2010.12.019 |
| Popis: | Helicobacter pylori, the major cause of gastric cancer, have mechanisms that allow colonization of the inhospitable gastric mucosa, including enzymes such as superoxide dismutase (SOD) which protect against reactive oxygen species. As SOD is essential for in vivo colonization, we theorized it might constitute a viable vaccine target. H. pylori SOD was expressed in E. coli and a purified recombinant protein used to vaccinate mice, prior to live H. pylori challenge. Partial protective immunity was induced, similar to that commonly observed with other antigens tested previously. This suggests SOD may have utility in a combination vaccine comprising several protective antigens. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect