Outcome and One Year Follow-up of Intra-arterial Staphylokinase in 191 Patients with Peripheral Arterial Occlusion
| Autor: | Luc Stockx, André Nevelsteen, Stephane Heymans, Yves Laroche, Desire Collen, Steven Vanderschueren, Raymond Verhaeghe, Hendrik Lacroix |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Embolism Arterial Occlusive Diseases Hemorrhage Revascularization Amputation Surgical Fibrinolytic Agents Risk Factors medicine Humans Thrombolytic Therapy Survival rate Vascular Patency Aged Peripheral Vascular Diseases Gangrene Hemostasis Vascular disease business.industry Graft Occlusion Vascular Hemodynamics Metalloendopeptidases Thrombosis Blood Proteins Hematology Middle Aged medicine.disease Arterial occlusion Recombinant Proteins Surgery Survival Rate Treatment Outcome Injections Intra-Arterial Drug Evaluation Female medicine.symptom Claudication business Fibrinolytic agent Follow-Up Studies |
| Zdroj: | Thrombosis and Haemostasis. 83:666-671 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1055/s-0037-1613889 |
| Popis: | SummaryWild-type or equipotent variants of recombinant staphylokinase (rSak) were given intra-arterially (as a 2 mg bolus injection followed by an infusion of 1 mg/h or 0.5 mg/h overnight, with concomitant heparin [1000 IU/h]) to 191 patients of less than 80 years (62 ± 1 years, mean ± SEM), with a peripheral arterial occlusion (PAO) of less than 120 days (mean 14 ± 1 days, median 11 days, 5 to 95 percentiles 3 to 30 days). Ninety nine patients presented with acute or subacute ischemia, 57 with severe claudication, 33 with chronic rest pain and 2 with gangrene. Occlusion occurred in 122 native arteries and in 69 grafts. Revascularization was complete in 83 percent (158/191), partial in 13 percent (24/191) and absent in 4 percent (7/191) after administration of 12 ± 0.5 mg rSak over 14 ± 0.7 h. Complete revascularization of acute occlusions of popliteal or more distal arteries was less frequent (60 percent, 15/25) than of acute occlusions of more proximal native arteries (95 percent, 37/39, p In conclusion, rSak appears to be a highly effective thrombolytic agent in patients with PAO, resulting in a low one month mortality (3.1 percent) and a high one year amputation free survival (84 percent), with an acceptable incidence of major bleedings, but with occasional fatal intracranial hemorrhages. |
| Databáze: | OpenAIRE |
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