Neuroanatomical assessment of biological maturity
| Autor: | Thomas Ernst, Sarah S. Murray, David G. Amaral, Cinnamon S. Bloss, Donald J. Hagler, Terry L. Jernigan, Joshua M. Kuperman, Vijay K. Venkatraman, Walter E. Kaufmann, David N. Kennedy, Timothy T. Brown, Elizabeth R. Sowell, Jean A. Frazier, Linda Chang, Tal Kenet, Matthew Erhart, Anders M. Dale, Natacha Akshoomoff, Yoonho Chung, Connor J. McCabe, B. J. Casey, Jeffrey R. Gruen |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Postmortem studies Aging Biological maturity Brain mapping Medical and Health Sciences Nerve Fibers Myelinated 0302 clinical medicine Nerve Fibers Neural Pathways Child Pediatric Cerebral Cortex Brain Mapping medicine.diagnostic_test Agricultural and Biological Sciences(all) 05 social sciences Brain Human brain Biological Sciences Magnetic Resonance Imaging medicine.anatomical_structure Cerebral cortex Child Preschool Neurological Biomedical Imaging Female General Agricultural and Biological Sciences Adolescent Biology 050105 experimental psychology General Biochemistry Genetics and Molecular Biology White matter 03 medical and health sciences Young Adult medicine Humans 0501 psychology and cognitive sciences Preschool Postnatal brain Biochemistry Genetics and Molecular Biology(all) Psychology and Cognitive Sciences Neurosciences Magnetic resonance imaging Brain Disorders Myelinated Neuroscience 030217 neurology & neurosurgery Biomarkers Developmental Biology |
| Zdroj: | Current biology : CB, vol 22, iss 18 Brown, TT; Kuperman, JM; Chung, Y; Erhart, M; McCabe, C; Hagler, DJ; et al.(2012). Neuroanatomical assessment of biological maturity. Current Biology, 22(18), 1693-1698. doi: 10.1016/j.cub.2012.07.002. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2kp2s13d |
| ISSN: | 1879-0445 |
| DOI: | 10.1016/j.cub.2012.07.002. |
| Popis: | Structural MRI allows unparalleled in vivo study of the anatomy of the developing human brain. For more than two decades [1], MRI research has revealed many new aspects of this multifaceted maturation process, significantly augmenting scientific knowledge gathered from postmortem studies. Postnatal brain development is notably protracted and involves considerable changes in cerebral cortical [2-4], subcortical [5], and cerebellar [6, 7] structures, as well as significant architectural changes in white matter fiber tracts [8-11] (see [12]). Although much work has described isolated features of neuroanatomical development, it remains a critical challenge to characterize the multidimensional nature of brain anatomy, capturing different phases of development among individuals. Capitalizing on key advances in multisite, multimodal MRI, and using cross-validated nonlinear modeling, we demonstrate that developmental brain phase can be assessed with much greater precision than has been possible using other biological measures, accounting for more than 92% of the variance in age. Further, our composite metric of morphology, diffusivity, and signal intensity shows that the average difference in phase among children of the same age is only about 1 year, revealing for the first time a latent phenotype in the human brain for which maturation timing is tightly controlled. Video Abstract: © 2012 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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