Ventricular Irritability Associated with the Use of Naloxone Hydrochloride: Two Case Reports and Laboratory Assessment of the Effect of the Drug on Cardiac Excitability
| Autor: | Thomas A. Clark, Paul R. Hickey, Lawrence L. Michaelis, William M. Dixon |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Pulmonary and Respiratory Medicine Drug Cardiac Complexes Premature Heart Ventricles media_common.quotation_subject Aortic Valve Insufficiency Diastole Anesthesia General Irritability Ventricular tachycardia Naloxone Hydrochloride Dogs Tachycardia medicine Animals Humans cardiovascular diseases Cardiac Surgical Procedures Aged media_common Postoperative Care Fibrillation Morphine Naloxone business.industry VENTRICULAR IRRITABILITY Heart Middle Aged medicine.disease Aortic Aneurysm Heart Valve Prosthesis Anesthesia Ventricular Fibrillation cardiovascular system Female Surgery medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The Annals of Thoracic Surgery. 18:608-614 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/s0003-4975(10)64408-6 |
| Popis: | Two instances of ventricular tachycardia and fibrillation have followed the injection of naloxone hydrochloride (Narcan) that had been given to reverse the effects of morphine following cardiac surgical procedures. Injection of the drug into 5 dogs that had received morphine was associated with ventricular extrasystoles in 2 animals, although no increase in ventricular excitability could be demonstrated as measured by either strength/interval curves or ventricular diastolic threshold. Naloxone hydrochloride should be used with caution in patients with cardiac irritability. |
| Databáze: | OpenAIRE |
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