Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women

Autor: Muñoz, Nubia, Hernandez-Suarez, G., Méndez, F., Molano, Monica, Posso, H., Moreno Aguado, Víctor, Murillo, R., Ronderos, M., Meijer, Chris J. L. M., Muñoz, Á., INC HPV Study Group
Přispěvatelé: Universitat de Barcelona, Pathology, CCA - Disease profiling
Rok vydání: 2009
Předmět:
Adult
Risk
Papillomavirus vaccines
Cancer Research
medicine.medical_specialty
Adolescent
Papillomaviruses
Epidemiology
Vacuna del papil·lomavirus
Risk factors in diseases
Uterine Cervical Neoplasms
Dones
HPV vaccines
cervical intraepithelial neoplasia
Colombia
Colòmbia
Cervical intraepithelial neoplasia
Cohort Studies
Coll uterí
Internal medicine
Humans
Medicine
Women
Risk factor
human papillomavirus
Papil·lomavirus
Aged
Tumors
Aged
80 and over
Gynecology
Human papillomavirus 16
Factors de risc en les malalties
business.industry
Papillomavirus Infections
HPV infection
persistence
Middle Aged
Viral Load
Uterine Cervical Dysplasia
medicine.disease
female genital diseases and pregnancy complications
Cervix uteri
Oncology
High Grade Cervical Intraepithelial Neoplasia
Cohort
Female
business
Viral load
Cohort study
Zdroj: Recercat. Dipósit de la Recerca de Catalunya
instname
British Journal of Cancer, 100(7), 1184-1190. Nature Publishing Group
British Journal of Cancer
Munoz, N, Hernandez-Suarez, G, Mendez, F, Molano, M, Posso, H, Moreno, V, Murillo, R, Ronderos, M, Meijer, C J L M & Munoz, A 2009, ' Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women ', British Journal of Cancer, vol. 100, no. 7, pp. 1184-1190 . https://doi.org/10.1038/sj.bjc.6604972
Dipòsit Digital de la UB
Universidad de Barcelona
ISSN: 1532-1827
0007-0920
DOI: 10.1038/sj.bjc.6604972
Popis: Little is known about the dynamics of human papillomavirus (HPV) infection and subsequent development of high-grade cervical intraepithelial neoplasia (CIN2/3), particularly in women >30 years of age. This information is needed to assess the impact of HPV vaccines and consider new screening strategies. A cohort of 1728 women 15-85 years old with normal cytology at baseline was followed every 6 months for an average of 9 years. Women with squamous intraepithelial lesions were referred for biopsy and treatment. The Kaplan-Meier method was used to estimate the median duration of infection and Cox regression analysis was undertaken to assess determinants of clearance and risk of CIN2/3 associated with HPV persistence. No difference in the likelihood of clearance was observed by HPV type or woman's age, with the exception of lower clearance for HPV16 infection in women under 30 years of age. Viral load was inversely associated with clearance. In conclusion, viral load is the main determinant of persistence, and persistence of HPV16 infections carry a higher risk of CIN2/3.
Databáze: OpenAIRE
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