Influence of timing and magnitude of arterial wave reflection on left ventricular relaxation
| Autor: | Toshiro Miura, Takashi Fujii, Shigeki Kobayashi, Masafumi Yano, Michihiro Kohno, Masunori Matsuzaki, Tomoko Ohkusa, Masakazu Obayashi, Kohzaburo Seki |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
medicine.medical_specialty Heart disease Heart Diseases Physiology Hemodynamics Magnitude (mathematics) Aorta Thoracic Blood Pressure Coronary Disease Ventricular Function Left Dogs Afterload Heart Rate Physiology (medical) Internal medicine Coronary Circulation medicine Animals Humans Wave impedance Aorta Abdominal Pulse Aged business.industry Blood flow Middle Aged medicine.disease Femoral Artery Vasoconstriction Anesthesia Circulatory system cardiovascular system Cardiology Relaxation (physics) Regression Analysis Cardiology and Cardiovascular Medicine business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0363-6135 |
| Popis: | The influence of timing and magnitude of arterial wave reflection (WR) on afterload-dependent relaxation was evaluated in patients with a variety of heart diseases ( group 1, age < 30 yr; group 2, age > 40 yr) and in dogs. While both femoral arteries were compressed (FC), WR returned just after the dicrotic notch (early diastole) in group 1but before the dicrotic notch (late systole) in group 2. The time constant of the left ventricular pressure decay (τ) was shortened during FC in group 1, whereas it was prolonged in group 2. In dogs, a constriction of the thoracic aorta induced a late systolic augmentation of WR with a prolongation of τ (cf. group 2), whereas constriction of the lower abdominal aorta induced an early diastolic augmentation of WR with a shortening of τ (cf. group 1). With aortic constriction, coronary flow increased, and there was a close correlation between the peak change in backward aortic pressure and that in coronary flow regardless of the timing of WR. Thus the time at which WR returns during the cardiac cycle may have an important effect on left ventricular relaxation and coronary flow. |
| Databáze: | OpenAIRE |
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