Mild and Efficient Trimethylsilylcyanation of Ketones Catalysed by PNP Chloride
| Autor: | Marc Taillefer, Nicolas J. Rahier, Marie-Agnès Lacour |
|---|---|
| Přispěvatelé: | Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC) |
| Rok vydání: | 2011 |
| Předmět: |
Solvent free
ketones 010405 organic chemistry Chemistry Organic Chemistry General Chemistry 010402 general chemistry 01 natural sciences Chloride Catalysis 0104 chemical sciences organocatalysts aldehydes medicine Organic chemistry solventfree trimethylsilylcyanation [CHIM.CHEM]Chemical Sciences/Cheminformatics medicine.drug |
| Zdroj: | Chemistry-A European Journal Chemistry-A European Journal, Wiley-VCH Verlag, 2011, 17 (44), pp.12276-12279. ⟨10.1002/chem.201101195⟩ |
| ISSN: | 0947-6539 1521-3765 |
| Popis: | International audience; Mild & green: The commercially and readily available PNPCl behaves as a very effective catalyst for the synthesis of various trimethylsilyl cyanohydrins from a wide range of aliphatic, cyclic, α,β-unsaturated and aromatic ketones. The method proceeds at room temperature in solvent-free conditions, in the presence of very small amounts of catalyst (see scheme). |
| Databáze: | OpenAIRE |
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