Antiphage activity of sera during phage therapy in relation to its outcome
| Autor: | Wojciech Fortuna, Krzysztof Szufnarowski, Ewa Olchawa, Maciej Żaczek, Marzanna Łusiak-Szelachowska, Andrzej Górski, Ewa Jończyk-Matysiak, Sławomir Letkiewicz, Kinga M Walaszek, Paweł Rogóż, Ryszard Międzybrodzki, Beata Weber-Dąbrowska |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Phage therapy viruses medicine.medical_treatment 030106 microbiology Bacterial Infections Biology Antibodies Viral Gram-Positive Bacteria Microbiology Neutralization 03 medical and health sciences 030104 developmental biology Neutralization Tests Neutralization test Gram-Negative Bacteria Immunology Healthy volunteers medicine Humans Phage Therapy |
| Zdroj: | Future Microbiology. 12:109-117 |
| ISSN: | 1746-0921 1746-0913 |
| DOI: | 10.2217/fmb-2016-0156 |
| Popis: | Aim: The aim was to study the association between the phage neutralization of patients’ sera and the clinical outcome of phage therapy (PT). Patients: About 62 patients with various bacterial infections receiving PT as well as 30 healthy volunteers were studied. Materials & methods: Antiphage activity of sera (AAS) was examined using the phage neutralization test of different types of phages before and during PT in relation to the route of phage administration and correlated with the results of PT. Results & conclusion: The analysis of the association between AAS level and clinical results indicated that the level of AAS is not correlated with the outcome of PT. |
| Databáze: | OpenAIRE |
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