Local Delivery of Mometasone Furoate from an Eluting Endotracheal Tube Reduces Airway Morbidity Following Long-Term Animal Intubation
| Autor: | Amani Daoud, Boris Fichtman, Netanel Eisenbach, Eyal Zussman, Offir Ertracht, Amnon Harel, Forsan Jahshan, Aiman Abu Ammar, Eyal Sela, Shaul Atar, Maayan Gruber |
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| Rok vydání: | 2022 |
| Předmět: |
Male
medicine.medical_treatment Biomedical Engineering Mometasone furoate Biocompatible Materials Biomaterials Rats Sprague-Dawley Materials Testing Airway morbidity medicine Intubation Intratracheal Intubation Animals Particle Size Endotracheal tube business.industry Biochemistry (medical) General Chemistry Respiration Artificial Rats Anesthesia Airway business Mometasone Furoate hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | ACS applied bio materials. 4(5) |
| ISSN: | 2576-6422 |
| Popis: | upper airway complications are common sequelae of endotracheal tube (ETT) intubation, and systemic corticosteroids are considered a mainstay treatment for this problem. Drug-eluting ETT may present an attractive option for topical steroid delivery while avoiding systemic side effects and improving the therapeutic outcome. The objective of the present study is to evaluate the reduction of tube-related tracheal morbiditysteroid-eluting ETTs were coated by poly(lactic-the blank-ETT group exhibited a significant increase in tracheal mucosal thickness compared to the loaded-ETT and control groups. Average tracheal mucosal thickness was 112 ± 34, 242 ± 49, and 113 ± 43 μm in the control, blank-ETT, and loaded-ETT groups, respectively. The blank-ETT group exhibited a significant increase in tracheal fibrosis compared to the loaded-ETT and control groups. Relative fibrosis values were 0.07 ± 0.05, 0.154 ± 0.1, and 0.0984 ± 0.084% for the control, blank-ETT, and loaded-ETT groups, respectively. While SEM imaging showed normal surface structures in the control group, intubated blank-ETT rats showed severe surface structural damage, whereas only mild damage was observed in the loaded-ETT group.local sustained release of MF |
| Databáze: | OpenAIRE |
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