Impact of recurrent laryngeal nerve lesion on oropharyngeal muscle activity and sensorimotor integration in an infant pig model
| Autor: | Allan J. Thexton, Jocelyn Ohlemacher, Katherine R. DeLozier, Francois D. H. Gould, Rebecca Z. German |
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| Rok vydání: | 2018 |
| Předmět: |
Swine
Physiology Infrahyoid muscles Musculoskeletal Physiological Phenomena Oropharynx Sensory system Electromyography Lesion 030507 speech-language pathology & audiology 03 medical and health sciences 0302 clinical medicine Tongue Swallowing Neck Muscles Physiology (medical) otorhinolaryngologic diseases medicine Recurrent laryngeal nerve Animals medicine.diagnostic_test Recurrent Laryngeal Nerve business.industry digestive oral and skin physiology Anatomy Dysphagia Deglutition medicine.anatomical_structure Animals Newborn Pharynx Sensorimotor Cortex Larynx medicine.symptom Deglutition Disorders 0305 other medical science business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Journal of Applied Physiology. 125:159-166 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00963.2017 |
| Popis: | The successful performance of a swallow requires dynamic integration between a wide range of sensory inputs and muscle activities to produce the coordinated kinematics of oropharyngeal structures. Damage to the recurrent laryngeal nerve (RLN) produces dysphagia in infants, with food or liquid entering the airway despite this nerve having minimal direct sensory or motor connections to the act of swallowing, apart from vocal fold closure. Previous results have demonstrated that a complete RLN lesion disrupts both performance and kinematics before initiation of the pharyngeal swallow in infants. We tested the hypothesis that a RLN lesion produces changes in the normal activity of oral floor, tongue, and infrahyoid muscles during a swallow. We recorded swallowing in our validated infant pig model, with synchronous high-speed imaging and fine-wire, chronic electromyography. We found changes in the timing, duration, and amplitude of the motor pattern in an array of muscles that are supplied by several different cranial and cervical nerves. Some of these changes in muscle activity are associated with the preparatory aspects of bolus aggregation or movement and so occur before the pharyngeal swallow. Taken with previous biomechanical results, these patterns suggest an intricate brain stem sensorimotor integration that occurs as part of a swallow. In particular, the execution of oral motor function is changed as a result of this simple lesion. NEW & NOTEWORTHY Damage to the recurrent laryngeal nerve compromises swallowing despite an absent or minimal contribution to either the motor or sensory aspects of this function. This study documents EMG changes, following RLN lesion, to non-RLN innervated muscles that are active during swallowing in an infant model. Some of these muscles fire before the pharyngeal swallow and are associated with the preparatory aspects of bolus aggregation and movement, suggesting important sensorimotor integration at a brain stem level. |
| Databáze: | OpenAIRE |
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