The predictive role of bioeffect dose models in radiation-induced late effects in glottic cancers
| Autor: | S.M. Deore, Ketayun A. Dinshaw, Vinay Sharma, S.J. Supe |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cancer Research
medicine.medical_specialty Cord medicine.medical_treatment Urology India Radiation induced Vocal Cords Dose per fraction Models Biological Carcinoma Humans Medicine Radiology Nuclear Medicine and imaging Laryngeal Neoplasms Retrospective Studies Radiation Radiotherapy business.industry Radiotherapy Dosage Retrospective cohort study Laryngeal Edema medicine.disease Radiation therapy Oncology Toxicity Carcinoma Squamous Cell business Nuclear medicine Complication |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 23:281-284 |
| ISSN: | 0360-3016 |
| Popis: | Late radiation-induced laryngeal oedema for different doses per fraction was analyzed in 208 cases with squamous cell carcinoma of the vocal cord. The series comprised 156 cases with T1N0M0 and 52 cases with T2N0M0 lesions. Radical radiotherapy was given with three different regimens delivering 3.33 Gy, 2.5 Gy, and 2.25 Gy per fraction. There were 52 cases of late radiation-induced laryngeal oedema. A strong correlation (p less than 0.015) between the dose per fraction and the risk of the late complication in the vocal cord has been demonstrated. The analysis suggests that the empirical models like Nominal Standard Dose (NSD) or Time-Dose Factors (TDF) do not predict correctly the late normal tissue reactions for different dose fractionations. The analysis with extrapolated response dose (ERD) values of the linear-quadratic (L-Q) model also fail to correlate with the late complications (p greater than 0.5). Care should be exercised when using these bioeffect dose models to calculate regimens iso-effective for late damage, even when modest changes in fraction size from 2 to 3 Gy are contemplated. |
| Databáze: | OpenAIRE |
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