Interleukin 6 as a marker of severe bacterial infection in children with sickle cell disease and fever: a case–control study
| Autor: | Elena María Rincón-López, María Luisa Navarro Gómez, Teresa Hernández-Sampelayo Matos, David Aguilera-Alonso, Eva Dueñas Moreno, Jesús Saavedra-Lozano, Begoña Santiago García, María del Mar Santos Sebastián, Marina García Morín, Cristina Beléndez Bieler, Jorge Lorente Romero, Elena Cela de Julián, F-DREP Study Group |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Fever Prevalence Infectious and parasitic diseases RC109-216 Anemia Sickle Cell Disease Gastroenterology Asymptomatic 03 medical and health sciences 0302 clinical medicine Medical microbiology Internal medicine medicine Humans Prospective Studies Child Interleukin-6 business.industry Research Sickle cell disease Case-control study Infant Bacterial Infections medicine.disease 030104 developmental biology Infectious Diseases Case-Control Studies Child Preschool 030220 oncology & carcinogenesis Cohort Coinfection Etiology Cytokines Female medicine.symptom Infection business Biomarkers |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-9 (2021) |
| ISSN: | 1471-2334 |
| Popis: | Background Etiological diagnosis of fever in children with sickle cell disease (SCD) is often challenging. The aim of this study was to analyze the pattern of inflammatory biomarkers in SCD febrile children and controls, in order to determine predictors of severe bacterial infection (SBI). Methods A prospective, case–control study was carried out during 3 years, including patients younger than 18 years with SCD and fever (cases) and asymptomatic steady-state SCD children (controls). Clinical characteristics and laboratory parameters, including 10 serum proinflammatory cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-17a, IFN-γ and TNF-α) and comparisons among study subgroups were analyzed. Results A total of 137 patients (79 cases and 58 controls) were included in the study; 78.5% males, median age 4.1 (1.7–7.5) years. Four cases were diagnosed with SBI, 41 viral infection (VI), 33 no proven infection (NPI) and 1 bacterial-viral coinfection (the latter excluded from the subanalyses). IL-6 was significantly higher in patients with SBI than in patients with VI or NPI (163 vs 0.7 vs 0.7 pg/ml, p Conclusion We found that IL-6 (with a cut-off value of 125 pg/ml) was an optimal marker for SBI in this cohort of febrile SCD children, with high PPV and NPV. Therefore, given its rapid elevation, IL-6 may be useful to early discriminate SCD children at risk of SBI, in order to guide their management. |
| Databáze: | OpenAIRE |
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