Ent-16 alpha-methylamino-3-methoxy-1,3,5(10)-estratrien-17 beta-ol hydrochloride, a selective anti-arrhytmic enantiosteroid

Autor:	A. Boyd, T. Sleigh, R. J. Marshall, F. J. Zeelen, B. Hindriksen, Marinus B. Groen, E. Winslow
Rok vydání:	1982
Předmět:	Male Magnetic Resonance Spectroscopy Optical Rotation Hydrochloride Stereochemistry medicine.medical_treatment Clinical Biochemistry Guinea Pigs Biochemistry Epithelium Steroid chemistry.chemical_compound Structure-Activity Relationship Endocrinology Plasma cholesterol medicine Potency Organic chemistry Animals Molecular Biology Pharmacology Chemistry Estriol Organic Chemistry Arrhythmias Cardiac Rats Inbred Strains Atrial Function Myocardial Contraction Rats Cholesterol Vagina Biological Assay Female Indicators and Reagents Anti-Arrhythmia Agents
Zdroj:	Steroids. 40(6)
ISSN:	0039-128X
Popis:	The title compound and its antipode with natural steroid configuration were synthesized and tested. Both compounds showed equal potency as anti-arrhythmic compounds. An additional effect found for the steroid with natural configuration was its plasma cholesterol lowering activity in the rat. This suggests that enantiosteroids may have a more selective action than the steroids with natural configuration
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949ae55e46a136b041ce80c8062aa237 https://pubmed.ncbi.nlm.nih.gov/7187712 Zobrazit plný text záznamu