The nonreceptor protein tyrosine kinase Src participates in every step of cancer-induced bone pain
Autor: | Yaoyuan Li, Yanju Bao, Yinggang Qin, Baojin Hua, Honggang Zheng |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Bone Neoplasms RM1-950 Cancer-induced bone pain Bone resorption 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Receptor Bone pain Pharmacology business.industry Bone metastasis Cancer General Medicine Cancer Pain medicine.disease 030104 developmental biology medicine.anatomical_structure src-Family Kinases 030220 oncology & carcinogenesis Cancer research Therapeutics. Pharmacology medicine.symptom business Tyrosine kinase Proto-oncogene tyrosine-protein kinase Src Sensory nerve Src |
Zdroj: | Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111822-(2021) |
ISSN: | 0753-3322 |
Popis: | Cancer-induced bone pain (CIBP) is a refractory form of pain that has a high incidence in advanced tumors. Src protein tyrosine kinase is mainly composed of six domains, with two states of automatic inhibition and activation. The modular domain allows Src to conveniently regulate by and communicate with a variety of proteins, directly or indirectly participate in each step of the CIBP process. Src is beneficial to the growth and proliferation of tumor cells, and it can promote the metastases of primary tumors to bone. In the microenvironment of bone metastasis, it mainly mediates bone resorption, activates related peripheral receptors to participate in the formation of pain signals, and may promote the generation of pathological sensory nerve fibers. In the process of pain signal transmission, it mainly mediates NMDAR and central glial cells to regulate pain signal intensity and central sensitization, but it is not limited to these two aspects. Both basic experimentation and clinical research have shown encouraging potential, providing new ideas and inspiration for the prevention and treatment of CIBP. |
Databáze: | OpenAIRE |
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