Effect of decorin protein administration on rat sciatic nerve injury: an experimental study
| Autor: | Selin Guler, Basar Koc, Alper Geyik, Muge Kiray, Serap Cilaker Micili, Haluk Vayvada |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Decorin Population Rats Sprague-Dawley Fibrosis Peripheral Nerve Injuries medicine Animals education Muscle Skeletal education.field_of_study business.industry Electromyography General Medicine Recovery of Function Sciatic nerve injury Nerve injury medicine.disease Rats Lumbosacral plexus Disease Models Animal Neurology Anesthesia Neurology (clinical) Sciatic nerve Bolus (digestion) medicine.symptom Sciatic Neuropathy business |
| Zdroj: | Neurological research. 44(3) |
| ISSN: | 1743-1328 |
| Popis: | Introduction Peripheral nerve traumas are common injuries in young adult population. The myriad of techniques and medications have been defined to obtain better recovery but none of them was proved to have superior effect. This study aims to determine the anti-fibrotic effect of the decorin on sciatic nerve injury in order to enhance functional outcome. Materials and Methods 24 12-week-old male Sprague-Dawley rats (350-400 gr) were divided into four groups. The sciatic nerve was dissected and exposed; a full-thickness laceration was created 1.5 cm proximal to the bifurcation point and 1.5 cm distal to where it originated from the lumbosacral plexus. Motor and sensory tests were conducted before and after the operations for evaluating the nerve healing. Results There was a statistically significant difference between DCN bolus and PBS bolus group. (p 0.05, p = 0.6623). Conclusion Decorin protein reduces the fibrosis and enhances the motor and sensory recovery both clinically and histologically. Despite the high cost, short half-life and production issues, this protein could be administered after the microsurgical repair but more studies are required to overcome the limitations. |
| Databáze: | OpenAIRE |
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