| Autor: |
David Benoist, Rachel Stones, Olivier Bernus, Mark J. Drinkhill, Ed White |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Biophysical Journal. 98(3) |
| ISSN: |
0006-3495 |
| DOI: |
10.1016/j.bpj.2009.12.1830 |
| Popis: |
Arrhythmic risk is increased in patients with heart failure. We have investigated the arrhythmic state of the failing right ventricle in a model of pulmonary hypertension (PAH).Wistar rats were injected intraperitoneally with monocrotaline (MCT, 60 mg/kg) to induce PAH and right ventricular failure within 3-4 weeks and compared to age-matched saline-injected animals (CON).In vivo measurement of ECG parameters using radiotelemetry indicated modification of T wave-parameters in MCT treated animals e.g. a prolonged QT interval (CON 49.7±2.0 vs. MCT 76.2±2.5 ms, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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