Fasting and Postprandial Activity of Brown Adipose Tissue in Healthy Men
| Autor: | Josefine E. Schopman, Wanda M. Admiraal, Maarten R. Soeters, Hein J. Verberne, Frits Holleman, A. Vrieze, Max Nieuwdorp |
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| Přispěvatelé: | General Internal Medicine, ACS - Amsterdam Cardiovascular Sciences, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Amsterdam Public Health, Endocrinology, Vascular Medicine, Nuclear Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Glucose uptake Standardized uptake value Carbohydrate metabolism Multimodal Imaging Young Adult Fluorodeoxyglucose F18 Internal medicine Brown adipose tissue medicine Humans Radiology Nuclear Medicine and imaging Meal business.industry Biological Transport Fasting Metabolism Postprandial Period Cold Temperature Adipocytes Brown Glucose Endocrinology medicine.anatomical_structure Postprandial Health Positron-Emission Tomography BAT activity Tomography X-Ray Computed business |
| Zdroj: | Journal of nuclear medicine, 53(9), 1407-1410. Society of Nuclear Medicine Inc. |
| ISSN: | 0161-5505 |
| Popis: | The role of brown adipose tissue (BAT) in adult metabolism is poorly understood. This study aimed to examine the differential effects of an overnight fast and the postprandial state on BAT activity. Methods: We included 10 healthy, lean male volunteers. BAT uptake of glucose was visualized using F-18-FDG PET/CT during mild cold exposure. Each subject underwent PET/CT twice. The first scan was obtained after an overnight fast; the second after a standardized meal. Results: F-18-FDG uptake in BAT was observed in 6 of 10 volunteers. These subjects were found to have a higher maximal standardized uptake value when fasting (median, 13.1 g/mL; range, 6.1-27.6 g/mL) than when in the postprandial state (median, 6.8 g/mL; range, 2.1-13.4 g/mL) (P = 0.03). Conclusion: Cold-stimulated F-18-FDG uptake by BAT in humans is more pronounced during fasting. The lower maximal standardized uptake value in the postprandial state may be explained by increased insulin-stimulated glucose uptake in muscle |
| Databáze: | OpenAIRE |
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