A Hypervariable Invertebrate Allodeterminant
| Autor: | Maria A. Moreno, Fadi G. Lakkis, Leo W. Buss, Stephen L. Dellaporta, Rafael D. Rosengarten, Anahid E. Powell, Matthew L. Nicotra, Jane Grimwood |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
0106 biological sciences
EVO_ECOL Molecular Sequence Data Sequence alignment Autoimmunity Major histocompatibility complex 010603 evolutionary biology 01 natural sciences General Biochemistry Genetics and Molecular Biology Article Major Histocompatibility Complex 03 medical and health sciences Hydractinia Animals Amino Acid Sequence Allorecognition Gene 030304 developmental biology Genetics 0303 health sciences Polymorphism Genetic biology Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) Marine invertebrates biology.organism_classification Transplantation Hydrozoa Phenotype Histocompatibility biology.protein Immunoglobulin superfamily General Agricultural and Biological Sciences Sequence Alignment |
| Zdroj: | Current Biology. (7):583-589 |
| ISSN: | 0960-9822 |
| DOI: | 10.1016/j.cub.2009.02.040 |
| Popis: | SummaryColonial marine invertebrates, such as sponges, corals, bryozoans, and ascidians, often live in densely populated communities where they encounter other members of their species as they grow over their substratum. Such encounters typically lead to a natural histocompatibility response in which colonies either fuse to become a single, chimeric colony or reject and aggressively compete for space. These allorecognition phenomena mediate intraspecific competition [1–3], support allotypic diversity [4], control the level at which selection acts [5–8], and resemble allogeneic interactions in pregnancy and transplantation [9–12]. Despite the ubiquity of allorecognition in colonial phyla, however, its molecular basis has not been identified beyond what is currently known about histocompatibility in vertebrates and protochordates. We positionally cloned an allorecognition gene by using inbred strains of the cnidarian, Hydractinia symbiolongicarpus, which is a model system for the study of invertebrate allorecognition. The gene identified encodes a putative transmembrane receptor expressed in all tissues capable of allorecognition that is highly polymorphic and predicts allorecognition responses in laboratory and field-derived strains. This study reveals that a previously undescribed hypervariable molecule bearing three extracellular domains with greatest sequence similarity to the immunoglobulin superfamily is an allodeterminant in a lower metazoan. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|