Granulocyte Kinetics in Donors Undergoing Filtration Leukapheresis
| Autor: | J. L. MacPherson, J. Nusbacher, TB Wiltbank, J. M. Rubins |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Neutropenia Premedication Immunology Kinetics Urology Blood Donors Granulocyte Dexamethasone law.invention Blood Transfusion Autologous Leukocyte Count Renal Dialysis Prednisone law hemic and lymphatic diseases Leukocytes Humans Immunology and Allergy Medicine Filtration business.industry Complement System Proteins Hematology Leukapheresis medicine.disease Neutrophilia Nylons medicine.anatomical_structure Hematocrit medicine.symptom business Granulocytes medicine.drug |
| Zdroj: | Transfusion. 16:56-62 |
| ISSN: | 0041-1132 |
| DOI: | 10.1046/j.1537-2995.1976.16176130838.x |
| Popis: | Normal blood donors undergoing filtration leukapheresis (FL) have a profound transient neutropenia early in the procedure which is followed by a "rebound" neutrophilia. This phenomenon occurs in unstimulated donors as well as in donors pretreated with either prednisone or dexamethasone. The mechanism for development of the neutropenia was investigated in volunteers throug a nylon filter at 37 C, a significant but transient neutropenia was observed. Plasma rendered cell and stroma-free achieved the same result indicating that plasma alone, when exposed to nylon fibers, is capable of producing neutropenia. |
| Databáze: | OpenAIRE |
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