HLA-ASSOCIATED SUSCEPTIBILITY TO ACQUIRED IMMUNODEFICIENCY SYNDROME IN ITALIAN PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
| Autor: | N. Eisera, Adriano Lazzarin, Mauro Moroni, Giovanna Fabio, Carlo Zanussi, R. Scorza Smeraldi |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Genetic Markers
Risk Acquired Immunodeficiency Syndrome business.industry General Medicine Human leukocyte antigen medicine.disease Virology HLA-A Acquired immunodeficiency syndrome (AIDS) Antigen AIDS-Related Complex HLA Antigens Immunopathology Immunology Genetic predisposition Humans Medicine Disease Susceptibility Sarcoma Viral disease business Sarcoma Kaposi Alleles |
| Zdroj: | The Lancet. 328:1187-1189 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(86)92197-5 |
| Popis: | To investigate the contribution of genetic susceptibility to infection with human immunodeficiency virus, 50 subjects with lymphadenopathy syndrome (LAS) and 7 subjects with acquired immunodeficiency syndrome (AIDS) and Kaposi's sarcoma were typed for HLA A, B, C, and DR antigens. The frequency of B35 was significantly higher in LAS patients who progressed to AIDS than in those who did not or in healthy controls. The association between DR5 and AIDS/Kaposi's sarcoma was also confirmed in these patients. |
| Databáze: | OpenAIRE |
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