Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder

Autor: Herbert Roeyers, Barbara Franke, Paraskevi Bitsakou, Dieter Baeyens, Jan K. Buitelaar, Aisling Mulligan, K Brookes, Michael Gill, Richard P. Ebstein, Philip Asherson, Hanna Christiansen, Amanda Meliá, Tobias Banaschewski, Stephen V. Faraone, Iris Manor, Margaret Thompson, Aribert Rothenberger, Joseph Sergeant, Henrik Uebel, Eric Taylor, Nanda Rommelse, Ana Miranda, Richard Anney, Jonna Kuntsi, Cathelijne J. M. Buschgens, Hans-Christoph Steinhausen, Jacques Eisenberg, Edmund J.S. Sonuga-Barke, Ueli C Müller, Robert D. Oades, Wai Chen
Přispěvatelé: Clinical Neuropsychology, University of Zurich
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Proband
Male
Genetics and epigenetic pathways of disease [NCMLS 6]
Intelligence
2804 Cellular and Molecular Neuroscience
Medizin
Neuroinformatics [DCN 3]
Receptors
Dopamine
Cohort Studies
2738 Psychiatry and Mental Health
0302 clinical medicine
Risk Factors
Perception and Action [DCN 1]
Medicine
Genetics(clinical)
Child
Genetics (clinical)
10058 Department of Child and Adolescent Psychiatry
3. Good health
Variable number tandem repeat
Psychiatry and Mental health
Child
Preschool
Female
Functional Neurogenomics [DCN 2]
Clinical psychology
2716 Genetics (clinical)
Adolescent
Genotype
Single-nucleotide polymorphism
610 Medicine & health
Mental health [NCEBP 9]
Genomic disorders and inherited multi-system disorders [IGMD 3]
03 medical and health sciences
Cellular and Molecular Neuroscience
Cognitive neurosciences [UMCN 3.2]
mental disorders
Attention deficit hyperactivity disorder
Humans
Genetic Predisposition to Disease
ddc:610
Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie
Psychosomatik und Psychotherapie des Kindes- und Jugendalters
Allele
Risk factor
Association (psychology)
Alleles
Dopamine Plasma Membrane Transport Proteins
business.industry
medicine.disease
030227 psychiatry
Genetic defects of metabolism [UMCN 5.1]
Genetic marker
Attention Deficit Disorder with Hyperactivity
business
030217 neurology & neurosurgery
Zdroj: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B(3), 316-319. Wiley-Liss Inc.
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 147, 3, pp. 316-9
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 147, 316-9
Sonuga-Barke, E, Brookes, K J, Buitelaar, J K, Anney, R J, Bitsakou, P, Baeyens, D, Buschgens, C J M, Chen, W, Christiansen, H, Eisenberg, J, Kuntsi, J, Manor, I, Melia, A, Mulligan, A, Rommelse, N N J, Müller, U, Uebel, H, Banaschewski, T, Ebstein, R, Franke, B, Gill, M, Miranda, A, Oades, R D, Roeyers, H, Rothenberger, A, Sergeant, J A, Steinhausen, H C, Thompson, M, Taylor, E, Asherson, P & Faraone, S V 2008, ' Intelligence in DSM IV combined type attention-deficit/ hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder ', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 147B, no. 3, pp. 316-319 . https://doi.org/10.1002/ajmg.b.30596
ISSN: 1552-4841
DOI: 10.1002/ajmg.b.30596
Popis: Contains fulltext : 69677.pdf (Publisher’s version ) (Closed access) A major goal of genetic studies of attention deficit hyperactivity disorder (ADHD) is to identify individual characteristics that might help segregate the disorder's inherent heterogeneity. [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] recently reported a potentially important association between two dopamine-related risk polymorphisms (DRD4 variable number tandem repeat (VNTR) in exon 3 and DAT1 VNTR in the 3' UTR) and lowered IQ in ADHD. The objective of the current study was to replicate the [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] findings in a clinical sample and to extend the analysis to a large range of alternative SNP markers of putative ADHD risk alleles identified in a recent study [Brookes et al. (2006); Mol Genet 11:934-953]. Participants were 1081 children and adolescents with a research-confirmed combined type ADHD diagnosis and 1300 unaffected siblings who took part in the International Multi-centre ADHD Genetics (IMAGE) project. They were recruited from multiple settings from across Europe: Belgium, Britain, Germany, Ireland, Israel, Netherlands, Spain and Switzerland. The results were that ADHD was associated with reduced IQ. However, there was no association between the two dopamine-related risk polymorphisms and IQ in either the probands or their siblings. Furthermore, other selected genetic markers previously demonstrated to be associated with ADHD in this sample were not associated with IQ. This large scale study with a clinically ascertained and regorously diagnosed sample failed to replicate the association between genetic polymorphisms in the dopamine system and IQ in ADHD. We also observed no association of other SNPs with IQ in ADHD.
Databáze: OpenAIRE
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