A Convenient Synthesis of 1-Benzyl-1,2,3,4-tetrahydroisoquinolines by Combined Strecker/Bruylants Reaction

Autor:	Eberhard Reimann, Christian Ettmayr
Rok vydání:	2004
Předmět:	chemistry Magnesium Strecker amino acid synthesis Halogenation Organic chemistry chemistry.chemical_element General Medicine General Chemistry
Zdroj:	Monatshefte f�r Chemie/Chemical Monthly. 135:1289-1295
ISSN:	1434-4475 0026-9247
DOI:	10.1007/s00706-004-0204-8
Popis:	Strecker reaction of iodophenethylamines with phenylacetaldehydes afforded the corresponding α-aminonitriles, which on treatment with i-propyl magnesium chloride underwent a Bruylants reaction to give the title compounds. Their structures were deduced by NMR and by an independent preparation starting from papaverine. The educts were easily available by standard procedures.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948ff3bf163072448d42b006ac0592bb https://doi.org/10.1007/s00706-004-0204-8 Zobrazit plný text záznamu Full text from SpringerLink