Growth Hormone-Binding Protein in Partially Hepatectomized Rats
| Autor: | Tamar Amit, Moussa B.H. Youdim, Yaacov Baruch, Rafael Enat, Pnina Hertz, Zeev Hochberg, Gideon Shoshany |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Biology Rats Sprague-Dawley Endocrinology Growth hormone-binding protein Internal medicine medicine Animals Hepatectomy Growth factor Binding protein Somatomedin Liver regeneration Liver Regeneration Rats Insulin-Like Growth Factor Binding Protein 1 Sprague dawley Liver metabolism Liver Female Carrier Proteins |
| Zdroj: | Hormone Research. 40:173-177 |
| ISSN: | 1423-0046 0301-0163 |
| DOI: | 10.1159/000183790 |
| Popis: | The role of the liver in regulating serum growth hormone-binding protein (GH-BP) was studied. We measured rat serum GH-BP and insulin-like growth factor 1 (IGF-1) 30 min to 96 h after 70% partial hepatectomy (PHP) or sham operation in adult male rats. Serum GH-BP declined sharply from 5.8 +/- 0.1% at baseline to 3.9 +/- 0.5% by 48 h following PHP. By 72 h serum GH-BP at baseline to 3.9 +/- 0.5% by 48 h following PHP. By 72 h serum GH-BP returned to baseline level and remained at that level 96 h postoperatively. In sham-operated female rats, serum GH-BP was about 2-fold higher than in males (10.5 +/- 1.46 versus 5.8 +/- 0.2%), whereas 24 h after hepatectomy a significant drop of about 50% was observed (p0.001). Serum IGF-1 decreased within 2-4 h postoperatively in both sham-operated and PHP groups, but thereafter was lower in the PHP rats, up to 48 h after operation, compared to sham-operated rats (p0.03). The study shows that the liver has an important role in the determination of serum GH-BP levels. The return to normal GH-BP level, even before the liver regained its full size following hepatectomy, suggests an increase in GH-BP production by the regenerating liver. |
| Databáze: | OpenAIRE |
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