Essential oil from Zanthoxylum tingoassuiba loaded into multilamellar liposomes useful as antimicrobial agents

Autor:	Eudes da Silva Velozo, Elaine C.M. Cabral-Albuquerque, Cássia Britto Detoni, S. V. A. Hohlemweger, Célia Maria de Souza Sampaio, T. F. Barros
Rok vydání:	2009
Předmět:	Zanthoxylum 1 2-Dipalmitoylphosphatidylcholine Pharmaceutical Science Bioengineering Sesquiterpene Staphylococcaceae law.invention chemistry.chemical_compound Colloid and Surface Chemistry Anti-Infective Agents law Oils Volatile Organic chemistry Physical and Theoretical Chemistry Lipid bilayer Essential oil Liposome Drug Carriers Chromatography biology Chemistry Vesicle Organic Chemistry biology.organism_classification Antimicrobial Liposomes Bacteria
Zdroj:	Journal of microencapsulation. 26(8)
ISSN:	1464-5246
Popis:	Zanthoxylum tingoassuiba essential oil (EO) is a complex mixture of organic compounds among which methyl-N-methylanthranilate and sesquiterpene alcohol alpha-bisabolol represent the main compounds. The essential oil antimicrobial activity was studied against bacteria and fungi cells by diffusion disk method and significant activity was observed against S. aureus, S. aureus isolated multi-resistant and the dermathophyte fungi. Essential oil from Zanthoxylum tingoassuiba loaded into DPPC multilamellar liposomes (MLV) was successfully produced through a thin film hydration method with mean diameter of 9.37 +/- 4.69 microm. The EO-loaded liposomes showed adequate sphericity and narrower size distribution than empty liposomes. Results also showed that Zanthoxylum tingoassuiba essential oil can be incorporated in appreciable amounts (43.7 +/- 6.0%) in the prepared vesicular dispersions. A strong interaction between essential oil and lipid bilayer was indicated by a significant decrease in T(m) of the EO-loaded liposomes related to empty vesicles. Essential oil showed incomplete release profile from liposomes, suggesting that EO-loaded liposomes will be useful in pharmaceutical applications to enhance essential oil targeting to cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948ee79026ab7258caac90bbc59ccbc6 https://pubmed.ncbi.nlm.nih.gov/19888877 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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