Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
| Autor: | Françoise Poirier, Etienne Gayat, Claude Delcayre, Jean-Marie Launay, Thibault Michel, Bocar Kane, Satoshi Kinugasa, Alain Cohen-Solal, Magali Genest, Matthieu Legrand, Maxime Coutrot, Louis Boutin, Sophie Vandermeersch, Christos E. Chadjichristos, Alexandre Mebazaa, Mathilde Prud’homme, Ravindra L. Mehta, Niki Prakoura, Jane-Lise Samuel |
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| Přispěvatelé: | Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Université Sorbonne Paris Nord, Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Phénotypage du petit animal (UMS28), Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Investigation Network Initiative Cardiovascular and Rénal Clinical Trialist (INI-CRCT), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Jacques Monod (IJM (UMR_7592)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University of California [San Diego] (UC San Diego), University of California (UC), Chadjichristos, Christos |
| Rok vydání: | 2019 |
| Předmět: |
WT
wild type lcsh:Diseases of the circulatory (Cardiovascular) system renal failure BUN blood urea nitrogen heart failure ICAM intercellular adhesion molecule Cardiovascular intensive care unit law.invention PRECLINICAL RESEARCH 0302 clinical medicine Fibrosis Aetiology Gal-3 galectin-3 UUO WT interleukin eGFR estimated glomerular filtration rate Acute kidney injury creatinine 3. Good health macrophages Kidney Disease Improving Global Outcome unilateral ureteral obstruction Galectin-3 intercellular adhesion molecule Cardiology and Cardiovascular Medicine medicine.medical_specialty Clinical Sciences Renal and urogenital 03 medical and health sciences BM IR ischemia-reperfusion NT-proBNP N-terminal-pro-brain natriuretic peptide KDIGO Kidney Disease Improving Global Outcome Prevention IL Gal-3 medicine.disease IL interleukin 030104 developmental biology lcsh:RC666-701 NT-proBNP IR 0301 basic medicine transforming growth factor Kidney Disease estimated glomerular filtration rate [SDV]Life Sciences [q-bio] TNF Cr creatinine 030204 cardiovascular system & hematology Cardiorespiratory Medicine and Haematology ischemia-reperfusion MCP modified citrus pectin law eGFR 2.1 Biological and endogenous factors KO knock-out TGF transforming growth factor Cr KDIGO TNF tumor necrosis factor [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology Blocking (radio) KO Intensive care unit ICU intensive care unit TGF Heart Disease acute kidney injury Cardiology wild type medicine.symptom ICAM bone marrow tumor necrosis factor Inflammation AKI acute kidney injury Immune system AKI Internal medicine BUN galectin-3 medicine UUO unilateral ureteral obstruction blood urea nitrogen knock-out N-terminal-pro-brain natriuretic peptide business.industry fibrosis Good Health and Well Being modified citrus pectin inflammation Heart failure MCP ICU BM bone marrow business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | JACC. Basic to translational science, vol 4, iss 6 JACC: Basic to Translational Science JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 717-732 (2019) JACC : Basic to Translational Science JACC : Basic to Translational Science, Elsevier on behalf of the American College of Cardiology Foundation, 2019, 4, pp.717-732. ⟨10.1016/j.jacbts.2019.06.005⟩ JACC : Basic to Translational Science, 2019, 4 (6), pp.717-732. ⟨10.1016/j.jacbts.2019.06.005⟩ |
| ISSN: | 2452-302X |
| Popis: | Visual Abstract Highlights • In 2 different mouse models, AKI increased Gal-3 expression and induced cardiac dysfunction, cardiac and systemic inflammation, cardiac macrophage infiltration, and fibrosis. • Cardiac consequences of AKI were dependent on the Gal-3 pathway and were prevented using Gal-3 knockout mice or modified citrus pectin as a pharmaceutical inhibitor. • Cardiac Gal-3 expression resulted from bone marrow-derived immune cells recruitment after AKI. • In critically ill patients, development of AKI is associated with increased plasma Gal-3 levels and increased biomarkers of cardiac injury and damage. Summary Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway. |
| Databáze: | OpenAIRE |
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