| Autor: |
Jie Chen, Zhiguo Chen, Zhi Chao Hou, Kevin B. Jacobs, Hong Li Lin, Sanford M. Dawsey, Maxwell P. Lee, Ilyar Sheyhidin, Ying Fa Zhou, Zi Ming Dong, Chang Wei Feng, Dong Xie, Ji Lin Li, Jing Jing Han, Fu Bao Chang, Yu Liu, Li Guo, Wei Zheng, Xiu Feng Yang, Lian Qun Zhang, Ai Fang Ji, Xin Song, Xiu-Min Li, Xiao Shan Feng, Hong Lei Li, Qin Xian Zhang, Tian Yun Wang, Zhaoming Wang, Song Liang Qiu, Dongyun Zhang, Li-Dong Wang, Sa Tang, Er Tao Guo, Ling Yuan, Zhi Gang Guo, Feng Li, Wu Wei, Xuejun Zhang, Jiang Man Li, Guang Yan Lei, Qi Zhou, Xia Yang, Guo Lan Xing, Linda M. Liao, Xian Bo Zuo, Zeng Lin Fan, Jia Chang, Min Han, Yan Rui Zhang, William Wheeler, Woon-Puay Koh, Amy Hutchinson, Ze Zhong Tang, Jian-Min Yuan, Jing Liu, Wen Yan Cui, Xi Chen, Xian Zeng Wang, Zhou Wang, Kai Yu, Xue Min Li, Jin Sheng Wang, Hai Liu, Joseph F. Fraumeni, Yin Li, Fu You Zhou, Yue Wu, Li Wang, Wan Li Yin, Chang Dong Lu, Lei Fan, Laurie Burdett, Ya-Li Liu, Bao Ping Chen, Zhong Min Fan, Liang Wang, Wong Ho Chow, Fu Sheng Gao, Yan Li, Long Qi Chen, Ran Wang, Fu Guo Zhu, Chao Yuan, Tai Jing Liu, Min Liu, Xiao-Ou Shu, Margaret A. Tucker, Zhi Qin Bao, Zhi Cai Liu, Li Yan Xu, Ti Ding, Jian Wei Kul, Shu Wei Ren, Xiang Zhuang, Stephen J. Chanock, Xian Chang Li, Zhi Yong Wu, Dan Li, Ji Li Chen, Jin Cheng Dong, Jing-Li Ren, Jian Xue Yang, Ai Li Li, Yi Ming Mao, Sheng Li Zhou, Chaoyu Wang, You-Lin Qiao, Zhi Qing Yuan, Wei Zhang, Xue Ke Zhao, Jeff Yuenger, She Gan Gao, Qing-Peng Kong, Charles C. Chung, Nan Hu, Bin Liu, Peng Zhang, Yong-Bing Xiang, Jin Wang, Wei Peng Wang, Carol Giffen, Hai Lin Liu, Yan Long Hu, Alisa M. Goldstein, Liangdan Sun, Lu Wen Wang, Jian Ting Zhao, Shuqing Chen, Wen Jing Fu, Sin Yong Lian, Wen Jun Yang, Christian C. Abnet, Jing Huang, Ming Guo, Wen Liang Zhu, Xin Ying Jian, Liu Qin Yang, Xue Pin Fan, Wen Bin Yue, Wancai Yang, Jin Yan, Ping Tao, Yuan Yuan, Jia Huang, Jin Chang Wei, En Min Li, Jin-Hu Fan, Neal D. Freedman, Qirenwang Qige, Guo Shun Ma, Yuan Fang Chen, Xiu Qin Peng, Yu Tang Gao, Philip R. Taylor, Meredith Yeager, Gao Fu Zhang, Jian Po Wang, Jian Jun Miao, Ji Li Cui, Jun Yan Hong |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Human Molecular Genetics. 21:2132-2141 |
| ISSN: |
1460-2083
0964-6906 |
| DOI: |
10.1093/hmg/dds029 |
| Popis: |
Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously published genome-wide scans that included a total of 2961 ESCC cases and 3400 controls. The meta-analysis revealed five SNPs at 2q33 with P5 × 10(-8), and the strongest signal was rs13016963, with a combined odds ratio (95% confidence interval) of 1.29 (1.19-1.40) and P= 7.63 × 10(-10). An imputation analysis of 4304 SNPs at 2q33 suggested a single association signal, and the strongest imputed SNP associations were similar to those from the genotyped SNPs. We conducted an ancestral recombination graph analysis with 53 SNPs to identify one or more haplotypes that harbor the variants directly responsible for the detected association signal. This showed that the five SNPs exist in a single haplotype along with 45 imputed SNPs in strong linkage disequilibrium, and the strongest candidate was rs10201587, one of the genotyped SNPs. Our meta-analysis found genome-wide significant SNPs at 2q33 that map to the CASP8/ALS2CR12/TRAK2 gene region. Variants in CASP8 have been extensively studied across a spectrum of cancers with mixed results. The locus we identified appears to be distinct from the widely studied rs3834129 and rs1045485 SNPs in CASP8. Future studies of esophageal and other cancers should focus on comprehensive sequencing of this 2q33 locus and functional analysis of rs13016963 and rs10201587 and other strongly correlated variants. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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