Induction of erythroid differentiation by the anthracycline antitumor antibiotic pyrromycin
| Autor: | András Schaefer, Hans Marquardt, G. Steinheider, Johannes Westendorf |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Friend leukemia
Anthracycline medicine.drug_class Health Toxicology and Mutagenesis Cellular differentiation Antibiotics Biology Toxicology Cell Line Mice chemistry.chemical_compound medicine Animals Humans Anthracyclines Erythropoiesis Inducer Aclarubicin chemistry.chemical_classification Antibiotics Antineoplastic Cell Biology Oligosaccharide Molecular biology Friend murine leukemia virus Aglycone chemistry Biochemistry Doxorubicin Cell culture Leukemia Erythroblastic Acute |
| Zdroj: | Cell Biology and Toxicology. 4:123-133 |
| ISSN: | 1573-6822 0742-2091 |
| Popis: | The oligosaccharide-anthracyclines, aclacinomycin A, marcellomycin and musettamycin, are potent inducers of erythroid differentiation in hemopoietic cells lines of rodent and human origin. The present studies revealed that pyrromycin, a closely related monosaccharide-anthracycline, induced erythroid differentiation in Friend leukemia cells and in the human leukemia cell line K 562. Pyrromycin, marcellomycin and musettamycin, which possess an identical aglycone structure containing a Cl-hydroxyl group, exhibited relatively low optimal inductive concentrations. In contrast, the optimal inductive concentration of aclacinomycin A, which lacks the Cl-hydroxyl group, was markedly higher, i.e., the differentiation inducing capacity was lower. It should be noted, however, that the yield of differentiated cells following treatment with the monosaccharide-anthracycline pyrromycin was distinctly lower than that after treatment with the oligo-saccharide-anthracyclines, aclacinomycin A, marcellomycin or musettamycin. Thus, our data indicate that the efficacy of anthracyclines to induce erythroid differentiation is related to a) the presence of a Cl-hydroxyl group in the aglycone and b) the presence of an oligosaccharide side chain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink