[Chinese herbal medicine enhances sexual function and c-Fos/nNOS expression in the nucleus accumbens of orchidectomized rats]
| Autor: | Xue Jin-juan, Liu Hongyu, Wang Xiao-yang, Zhai Haifeng, Cui Jianmei |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Sexual function Sexual Behavior physiological Central nervous system Decoction Nitric Oxide Synthase Type I Nucleus accumbens c-Fos Nucleus Accumbens Reinforcing kidney 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Animals Humans 0501 psychology and cognitive sciences Sex organ Testosterone 050102 behavioral science & comparative psychology Orchiectomy Medicine(all) biology business.industry 05 social sciences Chinese traditional General Medicine Orchidectomy Rats Sexual Dysfunction Physiological Endocrinology medicine.anatomical_structure biology.protein Female business Proto-Oncogene Proteins c-fos 030217 neurology & neurosurgery Drugs Chinese Herbal |
| Zdroj: | Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 36(3) |
| ISSN: | 0255-2922 |
| Popis: | Objective To determine whether the central nervous system is involved in the effect of Chinese herbal medicine on sexual function recovery in orchidectomized rats. Methods Orchidectomized rats were administered intragastrically with a decoction of “kidney-nourishing” Chinese herbal medicine once per day for 28 days. Accessory genital organ weight, plasma testosterone, and mating behavior were investigated. The expression of c-Fos and neuronal nitric oxide synthase (nNOS) in neuronal cells in the nucleus accumbens (NAc) was analyzed by immunohistochemistry. Results There was a decrease in accessory genital organ weight, plasma testosterone, and sexual behavior, as well as a low number of c-Fos-positive cells and a large nNOS-positive cell area in orchidectomized rats. Administration of the herbal medicine increased accessory genital organ weight, testosterone level, mating behavior, and c-Fos-positive cell number, while it decreased the nNOS-positive cell area in orchidectomized rats. Conclusion An increase of plasma testosterone after administration of “kidney-nourishing” herbal medicine might contribute to the elevated sexual function and activity in orchidectomized rats. In addition, a central nervous system mechanism, such as the functional alteration of NAc, might be involved. |
| Databáze: | OpenAIRE |
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