Immune-modulating and anti-inflammatory marine compounds against cancer
| Autor: | Cristina Florean, Marc Diederich, Mario Dicato |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
Aquatic Organisms Cancer Research medicine.drug_class medicine.medical_treatment Anti-Inflammatory Agents Inflammation Context (language use) Anti-inflammatory 03 medical and health sciences 0302 clinical medicine Immune system Cancer immunotherapy Neoplasms Tumor Microenvironment medicine Humans Tumor microenvironment Cancer prevention business.industry Cancer medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Immunotherapy medicine.symptom business |
| Zdroj: | Seminars in Cancer Biology. 80:58-72 |
| ISSN: | 1044-579X |
| DOI: | 10.1016/j.semcancer.2020.02.008 |
| Popis: | The recent advances in cancer immunotherapy confirm the crucial role of the immune system in cancer progression and treatment. Chronic inflammation and reduced immune surveillance are both features of the tumor microenvironment. Strategies aimed at reverting pro-tumor inflammation and stimulating the antitumor immune components are being actively searched, and the anticancer effects of many candidate drugs have been linked to their ability to modulate the immune system. Marine organisms constitute a rich reservoir of new bioactive molecules; some of them have already been exploited for pharmaceutical use, whereas many others are undergoing clinical or preclinical investigations for the treatment of different diseases, including cancer. In this review, we will discuss the immune-modulatory properties of marine compounds for their potential use in cancer prevention and treatment and as possible tools in the context of cancer immunotherapy. |
| Databáze: | OpenAIRE |
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