New azole antagonists with high affinity for the P2Y(1) receptor

Autor:	Patrick Y.S. Lam, Jean-Paul Daris, Carl Thibeault, Ruth R. Wexler, Ji Hua, Robert P. Rehfuss, Qimin Wu, Alexandre L'Heureux, Alain Martel, Rejean Ruel, Laura Price
Rok vydání:	2013
Předmět:	Platelet aggregation Stereochemistry Clinical Biochemistry Pharmaceutical Science Ring (chemistry) Biochemistry P2y1 receptor chemistry.chemical_compound Receptors Purinergic P2Y1 Structure-Activity Relationship Thiadiazoles Biomimetic Materials Drug Discovery Humans Urea skin and connective tissue diseases Molecular Biology chemistry.chemical_classification fungi Organic Chemistry Purinergic receptor body regions Kinetics chemistry Purinergic P2Y Receptor Antagonists Molecular Medicine Azole Protein Binding
Zdroj:	Bioorganicmedicinal chemistry letters. 23(12)
ISSN:	1464-3405
Popis:	Five-membered-ring heterocyclic urea mimics have been found to be potent and selective antagonists of the P2Y1 receptor. SAR of the various heterocyclic replacements is presented, as well as side-chain SAR of the more potent thiadiazole ring system which leads to thiadiazole 4c as a new antiplatelet agent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94869f87bcf45a4fbf5948460f5776ea https://pubmed.ncbi.nlm.nih.gov/23668989 Zobrazit plný text záznamu Full Text from ScienceDirect