LV Mass Independently Predicts Mortality and Need for Future Revascularization in Patients Undergoing Diagnostic Coronary Angiography
| Autor: | Yoko Mikami, Merril L. Knudtson, Ahmed Abdi-Ali, Mei Zhang, Danielle A. Southern, Robert J.H. Miller, Stephen B. Wilton, Andrew G Howarth, James A. White, Carmen P Lydell, Bobak Heydari, Mathew T. James |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Population Magnetic Resonance Imaging Cine Coronary Artery Disease 030204 cardiovascular system & hematology Revascularization Coronary Angiography Risk Assessment Severity of Illness Index Ventricular Function Left 030218 nuclear medicine & medical imaging Coronary artery disease 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine medicine Risk of mortality Myocardial Revascularization Humans Radiology Nuclear Medicine and imaging Registries education Aged Retrospective Studies Body surface area education.field_of_study Ejection fraction Ventricular Remodeling business.industry Hazard ratio Middle Aged medicine.disease Confidence interval Progression-Free Survival Cardiology Disease Progression Female Hypertrophy Left Ventricular Radiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | JACC. Cardiovascular imaging. 11(3) |
| ISSN: | 1876-7591 |
| Popis: | Objectives The goal of this study was to assess associations between left ventricular (LV) mass, all-cause mortality, and need for revascularization in patients undergoing coronary angiography. Background LV hypertrophy is associated with adverse cardiovascular outcomes in healthy subjects. However, its influence in those with known or suspected coronary artery disease is poorly understood. Methods A total of 3,754 patients (mean age 59.3 ± 13.1 years) undergoing invasive coronary angiography and cardiac magnetic resonance (CMR) (mean interval 1.0 ± 1.5 months) were studied. LV mass and volumes were determined from cine images and indexed to body surface area. Analyses were adjusted for CMR variables, medical comorbidities, and severity of coronary artery disease (Duke Jeopardy Score) and were stratified to LV function. Results At a median of 44.9 months, 315 patients (8.4%) died and 168 patients (4.5%) underwent revascularization. Multivariable analysis showed that each 10 g/m 2 increase in LV mass index was associated with a 6% greater risk of mortality (hazard ratio: 1.06; 95% confidence interval [CI]: 1.01 to 1.11; p = 0.02) and a 10% greater need for revascularization (hazard ratio: 1.10; 95% CI: 1.04 to 1.17; p 35% with respective hazard ratios of 2.93 (95% CI: 1.92 to 4.47) and 2.20 (95% CI: 1.21 to 3.98). Conclusions LV mass index is an independent predictor of all-cause mortality and need for revascularization. This finding establishes relevance for LV mass measurements in clinical decision-making surrounding both the need and timing of revascularization in this population. |
| Databáze: | OpenAIRE |
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