Finnish children who experienced narcolepsy after receiving the Pandemrix vaccine during the 2009–2010 H1N1 pandemic demonstrated high level of psychosocial problems

Autor: Marita Hovi, Hannu Heiskala, Eeva T. Aronen, Outi Saarenpää‐Heikkilä, Päivi Olsen, Pekka Nokelainen, Turkka Kirjavainen
Přispěvatelé: HUS Children and Adolescents, Lastenneurologian yksikkö, Children's Hospital, Clinicum, Lastenpsykiatria, Lastentautien yksikkö
Rok vydání: 2021
Předmět:
Zdroj: Acta Paediatrica. 111:850-858
ISSN: 1651-2227
0803-5253
DOI: 10.1111/apa.16233
Popis: https://doi.org/10.1111/apa.16233 ABSTRACT Aim We assessed psychosocial burdens in children who developed narcolepsy after receiving the Pandemrix H1N1 vaccine during the 2009-2010 pandemic. Parental quality of life was also assessed. Methods This multicentre study covered four of the five Finnish University Hospital Districts, which dealt with about 90% of the paediatric narcolepsy cases after the Pandemrix vaccination. The medical records of children diagnosed from 2010-2014 were reviewed. The questionnaires included the Youth Self Report (YSR), Children?s Depression Inventory (CDI), the Child Behaviour Checklist (CBCL) and questions on parental resources, stress and quality of life. Results We obtained the medical records of 94 children who were aged 5-17 years at the time of their narcolepsy diagnosis and questionnaire data for 73 of those children. Most children had strong narcolepsy symptoms 25% had CDI scores that suggested depression. In addition, 41% had total CBCL problem scores above the clinically significant limit and 48% were anxious, withdrawn and had somatic complaints. Sleep latency was weakly associated with the CBCL total problem score. Half of the children needed psychiatric interventions and parental stress was common. Conclusion Depression and behavioural problems were common in children with narcolepsy after the Pandemrix vaccination and their parents frequently reported feeling stressed.
Databáze: OpenAIRE
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