Conversion of stable renal allografts at one year from cyclosporin A to azathioprine: a randomized controlled study
| Autor: | S F Lui, J.F. Moorhead, J. E. Scoble, O. N. Fernando, Z. Varghese, Paul Sweny |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Graft Rejection Male Nephrology medicine.medical_specialty Time Factors Prednisolone Urology Cyclosporins Azathioprine Kidney Drug Administration Schedule law.invention chemistry.chemical_compound Randomized controlled trial law Internal medicine Cyclosporin a polycyclic compounds medicine Humans Randomized Controlled Trials as Topic Transplantation Creatinine Hematology business.industry Kidney metabolism Kidney Transplantation chemistry Female business medicine.drug |
| Zdroj: | Transplant International. 3:19-22 |
| ISSN: | 1432-2277 0934-0874 |
| DOI: | 10.1007/bf00333197 |
| Popis: | Seventy-seven stable, nondiabetic, cadaveric renal transplants were randomized at 1 year to convert from cyclosporin A to azathioprine or to continue on cyclosporin A. Prednisolone was increased twofold during the period of conversion, and there was a 3-week overlap period during which azathioprine and cyclosporin A were given. No grafts were lost due to rejection related to conversion, but 9 of the 33 patients who were randomized to convert experienced rejection episodes and 6 were returned to cyclosporin A. Conversion to azathioprine resulted in a drop in creatinine and improvement in blood pressure control. In the group randomized to stay on cyclosporin A, 6 patients had to be subsequently converted to azathioprine because of cyclosporin A toxicity in spite of well-controlled plasma levels. The creatinine levels after successful conversion remained stable whereas those of the patients continuing on cyclosporin A showed a progressive decline. We conclude that conversion from cyclosporin A to azathioprine can be achieved safely. Progressive deterioration in graft function with continuing cyclosporin A therapy does occur and should be taken as an indication for conversion. |
| Databáze: | OpenAIRE |
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