Mitochondria-localized caveolin in adaptation to cellular stress and injury

Autor:	Ravi C. Balijepalli, Sameh S. Ali, Yoshitaka Kawaraguchi, Mathivadhani Panneerselvam, Heidi N. Fridolfsson, Robert S. Ross, David M. Roth, Hideshi Okada, Piyush M. Patel, Michelle Jennings, Sarah E Kellerhals, Hemal H. Patel, Ana L. Moreno, Michael Y. Migita, Michael W. Kidd, J. Cameron Finley, Paul A. Insel, Ingrid R. Niesman, Qun Chen, Jacqueline A. Bonds, Brian P. Head, Edward J. Lesnefsky, Atsushi Miyanohara
Rok vydání:	2012
Předmět:	Male Mice Transgenic Mitochondrion Biology Biochemistry Caveolins Mitochondria Heart Research Communications Rats Sprague-Dawley chemistry.chemical_compound Mice Stress Physiological Caveolae Cell Line Tumor Caveolin Genetics Animals Humans Respiratory function Myocytes Cardiac Molecular Biology Heart metabolism chemistry.chemical_classification Mice Knockout Reactive oxygen species Superoxide Adaptation Physiological Cell biology Rats Mice Inbred C57BL Protein Transport chemistry Apoptosis Calcium Reactive Oxygen Species Biotechnology
Zdroj:	FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(11)
ISSN:	1530-6860
Popis:	We show here that the apposition of plasma membrane caveolae and mitochondria (first noted in electron micrographs >50 yr ago) and caveolae-mitochondria interaction regulates adaptation to cellular stress by modulating the structure and function of mitochondria. In C57Bl/6 mice engineered to overexpress caveolin specifically in cardiac myocytes (Cav-3 OE), localization of caveolin to mitochondria increases membrane rigidity (4.2%; P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947dfdffeba862fdd444117d71ddd14f https://pubmed.ncbi.nlm.nih.gov/22859372 Zobrazit plný text záznamu Plný text