Epidemiology of SV-40 simian virus in different regions of the Russian federation
| Autor: | B. A. Lapin, M. G. Chikobava |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Population Simian virus 40 Biology Simian General Biochemistry Genetics and Molecular Biology Virus Russia Young Adult Epidemiology medicine Animals Humans education Aged Poliomyelitis vaccine education.field_of_study Polyomavirus Infections General Medicine Middle Aged medicine.disease biology.organism_classification Virology Poliomyelitis Vaccination Tumor Virus Infections Immunology Female Horizontal transmission |
| Zdroj: | Bulletin of experimental biology and medicine. 148(6) |
| ISSN: | 1573-8221 |
| Popis: | Multiplication of poliomyelitis virus for vaccine production in 1955-1961 was realized in kidney cell culture from M. rhesus naturally infected with SV-40 simian virus. Hence, some lots of the vaccine were contaminated with this virus. It was found that SV-40 is oncogenic for laboratory rodents. Since 1963, in accordance with WHO recommendation, green monkey kidneys containing no SV-40 were used instead of M. rhesus kidneys. Overall vaccination of the population with poliomyelitis vaccine in 1955-1961 led to infection of many humans in Russia and many foreign countries with SV-40. The possibility of horizontal transmission of the virus was demonstrated. As a result, virus (its DNA sequences) was detected in individuals who were never vaccinated. Hundreds of reports, often contradictory, discuss this problem. Our study is based on the analyses of 460 blood specimens from subjects living in different regions of Russia (Krasnodar region, Moscow, Novosibirsk region, Krasnoyarsk territory). The percent of individuals infected with SV-40 varies from 16 to 49%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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