Resting mononuclear cell NR3C1 and SKA2 expression levels predict blunted cortisol reactivity to combat training stress among elite army cadets exposed to childhood adversity
| Autor: | Fortu Benarroch, Tanya Goltser-Dubner, Noa Itzhar, Ronen Segman, Ruth Giesser, Aron Mirman, Amit Shalev, Carmel Kalla, Amit Lotan, Omer Bonne, Esti Galili-Weisstub, Laura Canetti, Eyal Fruchter, Roni Haber, Inon Vashdi, Ariel Ben-Yehuda, Dalya Pevzner, Chen Saloner, Osnat Oz |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adolescent Hydrocortisone Chromosomal Proteins Non-Histone Physiology Peripheral blood mononuclear cell 03 medical and health sciences Cellular and Molecular Neuroscience Receptors Glucocorticoid 0302 clinical medicine Immune system Glucocorticoid receptor Adverse Childhood Experiences Humans Medicine Endocrine system Molecular Biology business.industry SKA2 Executive functions Psychiatry and Mental health Distress Military Personnel 030104 developmental biology Cohort business Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Molecular Psychiatry. 26:6680-6687 |
| ISSN: | 1476-5578 1359-4184 |
| DOI: | 10.1038/s41380-021-01107-z |
| Popis: | Childhood adversity (CA) may alter reactivity to stress throughout life, increasing risk for psychiatric and medical morbidity, yet long-term correlates of milder CA levels among high functioning healthy adolescents are less studied. The current study examined the prevalence and impact of CA exposure among a cohort of healthy motivated elite parachute unit volunteers, prospectively assessed at rest and at the height of an intensive combat-simulation exposure. We found significantly reduced gene expression levels in resting mononuclear cell nuclear receptor, subfamily 3, member 1 (NR3C1), and its transactivator spindle and kinetochore-associated protein 2 (SKA2), that predict blunted cortisol reactivity to combat-simulation stress among CA exposed adolescents. Long-term alterations in endocrine immune indices, subjective distress, and executive functions persist among healthy high functioning adolescents following milder CA exposure, and may promote resilience or vulnerability to later real-life combat exposure. |
| Databáze: | OpenAIRE |
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