A lab-on-phone instrument with varifocal microscope via a liquid-actuated aspheric lens (LAL)
| Autor: | Zheng Hong Lai, Hung Jui Huang, Li Han Kau, Yiin Kuen Fuh |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Microscope
Materials science Point-of-Care Systems Controller (computing) lcsh:Medicine Separator (oil production) 02 engineering and technology 01 natural sciences law.invention 010309 optics chemistry.chemical_compound Optics law 0103 physical sciences Focal length Fluidics lcsh:Science Lenses Microscopy Multidisciplinary Polydimethylsiloxane business.industry lcsh:R Equipment Design 021001 nanoscience & nanotechnology Lens (optics) Aspheric lens chemistry lcsh:Q 0210 nano-technology business Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 6, p e0179389 (2017) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0179389 |
| Popis: | In this paper, we introduce a novel concept of liquid-actuated aspheric lens (LAL) with a built-in aspheric polydimethylsiloxane lens (APL) to enable the design of compact optical systems with varifocal microscopic imaging. The varifocal lens module consists of a sandwiched structures such as 3d printed syringe pump functionally serves as liquid controller. Other key components include two acrylic cylinders, a rigid separator, a APL/membrane composite (APLMC) embedded PDMS membrane. In functional operation, the fluidic controller was driven to control the pressure difference and ALPMC deformation. The focal length can be changed through the pressure difference. This is achieved by the adjustment of volume change of injected liquid such that a widely tunable focal length. The proposed LAL can transform to 3 modes: microscopic mode (APLMC only), convex-concave mode and biconcave mode. It is noticeable that LAL in the operation of microscopic mode is tunable in focus via the actuation of APLMC (focal length is from 4.3 to 2.3 mm and magnification 50X) and can rival the images quality of commercial microscopes. A new lab-on-phone device is economically feasible and functionally versatile to offer a great potential in the point of care applications. |
| Databáze: | OpenAIRE |
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