Role of 3T multiparametric magnetic resonance imaging without endorectal coil in the detection of local recurrent prostate cancer after radical prostatectomy: the radiation oncology point of view

Autor:	José Manuel Rodríguez-Luna, Jose Luis R. Martin, Felipe Couñago, Antonio Maldonado, Manuel Recio, A.A. Diaz, Francisco José Marcos, Laura Cerezo, Israel Thuissard, Elia del Cerro
Rok vydání:	2015
Předmět:	Biochemical recurrence Male medicine.medical_specialty Urology Radiography medicine.medical_treatment Resonancia magnética nuclear (Medicina) Prostate cancer Interquartile range Próstata - Cáncer Medicine Humans Ciencias médicas Multiparametric Magnetic Resonance Imaging Aged Retrospective Studies Prostatectomy business.industry Prostate Cancer Prostatic Neoplasms Cáncer Middle Aged Prostate-Specific Antigen medicine.disease Magnetic Resonance Imaging Nephrology Radiation Oncology Radiology Neoplasm Recurrence Local business Nuclear medicine Diffusion MRI
Zdroj:	Scandinavian journal of urology. 49(5)
ISSN:	2168-1813
Popis:	The aims of this study were to evaluate the role of 3 tesla multiparametric magnetic resonance imaging (3TmMRI) without endorectal coil in the detection of radiographic local recurrences (rLRs) in a contemporary cohort of patients with prostate cancer who presented with biochemical recurrence after radical prostatectomy (RP) with low prostate-specific antigen (PSA) levels, and to identify clinical parameters associated with the 3TmMRI findings.Between 2009 and 2013, 57 patients with biochemical recurrence of prostate cancer after RP who were considered for salvage radiation therapy (SRT) were included. 3TmMRI with T2-weighted imaging, diffusion weighted imaging (DWI) and dynamic contrast-enhanced imaging without endorectal coil was carried out in all patients before treatment.In 14 out of 57 patients (24.56%) local recurrence was detected through 3TmMRI. Median pre-SRT PSA was 0.40 ng/ml (interquartile range 0.30-2.05 ng/ml). The recurrence was perianastomotic in eight out of 14 patients (57.14%) and retrovesical in six out of 14 patients (42.86%). The median size of the local recurrence was 15.2 mm (range 8.0-46.0 mm). The probability of rLR was significantly higher in patients with PSA levels above 0.5 ng/ml [adjusted odds ratio (OR) 6.25, 95% confidence interval (CI) 1.27-30.79, p = 0.02] or PSA doubling time (PSADT) over 14 months (adjusted OR 7.12, 95% CI 1.40-36.25, p = 0.01).This is the first study to find a significant relationship between the PSADT and the rLR through MRI. Patients with PSADT longer than 14 months or pre-SRT PSA above 0.5 ng/ml benefited most from 3TmMRI. Its routine use could have significant clinical implications for SRT.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947a4434303ca2f88ddae860e4ee6833 https://pubmed.ncbi.nlm.nih.gov/25652562 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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