Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric)
| Autor: | Jin Ho Chung, Ji-Yoon Noh, Moo-Yeol Lee, Kyung Min Lim, Yeryeon Jung, Ok-Nam Bae, Keunyoung Kim, Jung-Jun Kim, Ahmed Shah Syed, Chul Young Kim |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Curcumin Vascular smooth muscle Calcium Channels L-Type Stereochemistry Pharmaceutical Science Pharmacology Analytical Chemistry Inhibitory Concentration 50 03 medical and health sciences Ingredient chemistry.chemical_compound Curcuma Drug Discovery medicine Animals Phosphorylation Cytotoxicity IC50 030109 nutrition & dietetics Molecular Structure biology Calcium channel Organic Chemistry biology.organism_classification Rats 030104 developmental biology Complementary and alternative medicine chemistry Vasoconstriction Molecular Medicine medicine.symptom |
| Zdroj: | Journal of Natural Products. 80:196-200 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.6b00331 |
| Popis: | Despite the increasing attention on the therapeutic potential of Curcuma longa (turmeric), the biological activities of curcuminoids other than curcumin are not well understood. Here, we investigated antivasoconstrictive activities of C. longa extract and its ingredients using freshly isolated rat aortic rings. C. longa extract significantly suppressed agonist-stimulated vasoconstriction, and cyclocurcumin was found to be the most potent (IC50 against phenylephrine-induced vasoconstriction: 14.9 ± 1.0 μM) among the 10 tested ingredients including four curcuminoids. Cyclocurcumin significantly inhibited contraction of vascular smooth muscle, which was mediated by the suppression of myosin-light-chain phosphorylation and calcium influx via the L-type calcium channel. The inhibitory effect of cyclocurcumin was observed to be reversible and without cytotoxicity. Taken together, we demonstrated that cyclocurcumin, a bioactive ingredient in C. longa, may have a therapeutic potential as a novel antivasoconstrict... |
| Databáze: | OpenAIRE |
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