White Matter Integrity in the Fronto-striatal Accumbofrontal Tract Predicts Impulsivity
| Autor: | Alberto Del Arco, Katherine H. Karlsgodt, Toshikazu Ikuta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Individuality Striatum Medical and Health Sciences Nucleus Accumbens Behavioral Neuroscience 0302 clinical medicine Neural Pathways Prefrontal cortex Frontostriatal circuit 05 social sciences Experimental Psychology Middle Aged White Matter Psychiatry and Mental health Diffusion tensor imaging medicine.anatomical_structure Diffusion Tensor Imaging Neurology Biomedical Imaging Female medicine.symptom Psychology MRI Adult Impulsivity Cognitive Neuroscience Prefrontal Cortex Nucleus accumbens Basic Behavioral and Social Science 050105 experimental psychology Article 03 medical and health sciences Cellular and Molecular Neuroscience Accumbofrontal tract Clinical Research Behavioral and Social Science Fractional anisotropy Orbitofrontal cortex medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Psychology and Cognitive Sciences Neurosciences Corpus Striatum Brain Disorders Impulsive Behavior Neurology (clinical) Neuroscience 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Brain imaging and behavior, vol 12, iss 5 |
| Popis: | Frontostriatal projections have been shown to mediate impulsivity. Recent findings have demonstrated that the projection from the prefrontal cortex to the nucleus accumbens (the accumbofrontal tract) can be isolated by using probabilistic tractography on human brain MRI data, specifically, diffusion tensor images (DTI). Using DTI tractography, we isolated the tract and tested its association with the impulsivity. DTI data from 143 individuals obtained from Nathan Kline Institute-Rockland Sample was used along with the impulsivity measure assessed by the UPPS (urgency, premeditation, perseverance, and sensation seeking) impulsive behavior total score. Probabilistic tractography was first performed between the prefrontal cortex and nucleus accumbens, then, as a measure of white matter integrity in the tract, fractional anisotropy was calculated for each individual's tract. In the multiple regression, accumbofrontal FA showed significant positive association with the impulsivity, suggesting that the accumbofrontal tract integrity may contribute to individual differences in impulsivity. This study bridges the literature in rodents, in which this glutamatergic projection has been shown to mediate impulsive behavior, and the findings in humans which allow the in-vivo isolation of the tract and comparison with behavior. |
| Databáze: | OpenAIRE |
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