Sensitivity enhancement of DHR123 radio-fluorogenic nanoclay gel dosimeter by incorporating surfactants and halogenides
| Autor: | Takuya Maeyama, Anri Mochizuki, Yusuke Watanabe, Shinya Mizukami |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Tribromoacetic acid
Dosimeter 010308 nuclear & particles physics General Chemical Engineering Radiochemistry Quantum yield General Chemistry 01 natural sciences 030218 nuclear medicine & medical imaging Ionizing radiation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Yield (chemistry) 0103 physical sciences Dosimetry Irradiation Sodium dodecyl sulfate |
| Zdroj: | RSC Advances. 10:28798-28806 |
| ISSN: | 2046-2069 |
| Popis: | Dosimetry of spatial dose distribution of ionizing radiation in tissue equivalent materials is particularly important for cancer radiotherapy. Here, we describe a radio-fluorogenic gel-based dosimeter that has achieved 16 times higher sensitivity by incorporating surfactants and halogenides. The gel dosimeters were prepared from dihydrorhodamine 123 (DHR123) and small amounts of nano-sized clay and a radiosensitizer. By comprehensively changing the type of additives for the sensitizer (three surfactants: Triton X-100, sodium dodecyl sulfate (SDS) and cetyltrimethylammonium bromide, and three halogenides: trichloroacetic acid, tribromoacetic acid and 2,2,2-trichloroethanol), the increase in sensitivity can be explained by an increase in relative fluorescence quantum yield and an increase in radiation chemical yield. These highly sensitive gel dosimeters also show dose rate independent sensitivity under irradiation at 0.64 and 0.77 Gy min−1 using a 6 MV X-ray therapeutic beam from the medical linac. |
| Databáze: | OpenAIRE |
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