Effect of tobacco smoke on the knee-jerk reflex in man
| Autor: | M.S.G. Clark, M.J. Rand |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Adult
Male Nicotine Adolescent Knee Joint genetic structures Knee-jerk reflex Light smoker Tobacco smoke Cigarette smoking Reflex Tobacco mental disorders medicine Humans Cigarette smoke Pharmacology Electromyography business.industry Smoking Spinal reflex humanities nervous system diseases body regions Plants Toxic Depression Chemical Anesthesia Female business medicine.drug |
| Zdroj: | European Journal of Pharmacology. 3:294-302 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(68)90110-6 |
| Popis: | The knee-jerk reflex was elicited automatically in human volunteers every 10 sec. Cigarette smoking caused a decrease in the knee-jerk which was more pronounced in non-smokers and light smokers than in heavy smokers. Smoking cigarettes containing an amount of nicotine comparable to commercial cigarettes (2.1%) inhibited the knee-jerk in a significantly greater number of subjects than did smoking cigarettes with a low nicotine content (0.1%). The knee-jerk of some subjects was facilitated by the contemporaneous performance of a task; cigarette smoking depressed the knee-jerks of these subjects more than in subjects who showed little or no facilitation. It is suggested that the depression of the knee-jerk is due to the nicotine present in the cigarette smoke and that the so-called tranquillisation attributed to cigarette smoking may be related to inhibition of reflex mechanisms. |
| Databáze: | OpenAIRE |
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